Loriot et al., 2014 - Google Patents
Radiosensitization by a novel Bcl-2 and Bcl-XL inhibitor S44563 in small-cell lung cancerLoriot et al., 2014
View HTML- Document ID
- 8932824043605946939
- Author
- Loriot Y
- Mordant P
- Dugue D
- Geneste O
- Gombos A
- Opolon P
- Guegan J
- Perfettini J
- Pierre A
- Berthier L
- Kroemer G
- Soria J
- Depil S
- Deutsch E
- Publication year
- Publication venue
- Cell death & disease
External Links
Snippet
Radiotherapy has a critical role in the treatment of small-cell lung cancer (SCLC). The effectiveness of radiation in SCLC remains limited as resistance results from defects in apoptosis. In the current study, we investigated whether using the Bcl-2/Bcl-X L inhibitor …
- 208000000587 Small Cell Lung Carcinoma 0 title abstract description 88
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
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