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Tong et al., 2011 - Google Patents

Synergistic antitumor effect of dichloroacetate in combination with 5‐fluorouracil in colorectal cancer

Tong et al., 2011

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Document ID
8687108420219939090
Author
Tong J
Xie G
He J
Li J
Pan F
Liang H
Publication year
Publication venue
BioMed Research International

External Links

Snippet

Dichloroacetate (DCA), an inhibitor of pyruvate dehydrogenase kinase (PDK), has been recently demonstrated as a promising nontoxic antineoplastic agent that promotes apoptosis of cancer cells. In the present study, we aimed to investigate the antitumor effect of DCA …
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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