Jang et al., 2020 - Google Patents
Hydrophilic biocompatible poly (acrylic acid-co-maleic acid) polymer as a surface-coating ligand of ultrasmall Gd2O3 nanoparticles to obtain a high r1 value and T1 …Jang et al., 2020
View HTML- Document ID
- 8671736403835874673
- Author
- Jang Y
- Liu S
- Yue H
- Park J
- Cha H
- Ho S
- Marasini S
- Ghazanfari A
- Ahmad M
- Miao X
- Tegafaw T
- Chae K
- Chang Y
- Lee G
- Publication year
- Publication venue
- Diagnostics
External Links
Snippet
The water proton spin relaxivity, colloidal stability, and biocompatibility of nanoparticle- based magnetic resonance imaging (MRI) contrast agents depend on the surface-coating ligands. Here, poly (acrylic acid-co-maleic acid)(PAAMA)(Mw=~ 3000 amu) is explored as a …
- 239000002105 nanoparticle 0 title abstract description 180
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
- A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
- A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
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