Kitagawa et al., 2013 - Google Patents
Cloning and Heterologous Expression of the Aurachin RE Biosynthesis Gene Cluster Afford a New Cytochrome P450 for Quinoline N‐HydroxylationKitagawa et al., 2013
View PDF- Document ID
- 7706681194998426668
- Author
- Kitagawa W
- Ozaki T
- Nishioka T
- Yasutake Y
- Hata M
- Nishiyama M
- Kuzuyama T
- Tamura T
- Publication year
- Publication venue
- ChemBioChem
External Links
Snippet
Aurachin RE is a prenylated quinoline antibiotic that was first isolated from the genus Rhodococcus. It shows potent antibacterial activity against a variety of Gram‐positive bacteria. Here we have identified a minimal biosynthesis gene cluster for aurachin RE in …
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 C1=CC=C2C(=O)C(C/C=C(C)/CC/C=C(C)/CC(O)C=C(C)C)=C(C)N(O)C2=C1 0 title description 45
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