Li et al., 2003 - Google Patents
Bifidobacterium adolescentis as a delivery system of endostatin for cancer gene therapy: selective inhibitor of angiogenesis and hypoxic tumor growthLi et al., 2003
View PDF- Document ID
- 7692394203709466413
- Author
- Li X
- Fu G
- Fan Y
- Liu W
- Liu X
- Wang J
- Xu G
- Publication year
- Publication venue
- Cancer gene therapy
External Links
Snippet
In order to overcome difficulties that hampered widespread application of antiangiogenesis in cancer therapy, a highly specific delivery system may be engaged in vivo to deliver and express antiangiogenic genes. We selected a strain of Bifidobacterium adolescentis (B …
- 241000186018 Bifidobacterium adolescentis 0 title abstract description 103
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Micro-organisms or materials therefrom
- A61K35/74—Bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Li et al. | Bifidobacterium adolescentis as a delivery system of endostatin for cancer gene therapy: selective inhibitor of angiogenesis and hypoxic tumor growth | |
Lee et al. | Systemic administration of attenuated Salmonella choleraesuis carrying thrombospondin-1 gene leads to tumor-specific transgene expression, delayed tumor growth and prolonged survival in the murine melanoma model | |
Liu et al. | Vessel destruction by tumor-targeting Salmonella typhimurium A1-R is enhanced by high tumor vascularity | |
Nuyts et al. | Radio-responsive recA promoter significantly increases TNFα production in recombinant clostridia after 2 Gy irradiation | |
US12214004B2 (en) | Strains having effects of preventing or treating cancers | |
Xu et al. | A new expression plasmid in Bifidobacterium longum as a delivery system of endostatin for cancer gene therapy | |
Sasaki et al. | Genetically engineered Bifidobacterium longum for tumor‐targeting enzyme‐prodrug therapy of autochthonous mammary tumors in rats | |
Hu et al. | Bifidobacterium longum as a delivery system of TRAIL and endostatin cooperates with chemotherapeutic drugs to inhibit hypoxic tumor growth | |
Liu et al. | Anticancer efficacy of systemically delivered anaerobic bacteria as gene therapy vectors targeting tumor hypoxia/necrosis | |
Nguyen et al. | Genetically engineered Salmonella typhimurium as an imageable therapeutic probe for cancer | |
Zhu et al. | Antitumor effect of sFlt-1 gene therapy system mediated by Bifidobacterium Infantis on Lewis lung cancer in mice | |
Wei et al. | Bifidobacteria expressing tumstatin protein for antitumor therapy in tumor-bearing mice | |
Xiao et al. | A gene therapy for cancer based on the angiogenesis inhibitor, vasostatin | |
Gautam et al. | Inhibition of experimental lung metastasis by aerosol delivery of PEI–p53 complexes | |
Wang et al. | Bifidobacterium breve as a delivery vector of IL-24 gene therapy for head and neck squamous cell carcinoma in vivo | |
Zhang et al. | Cathelicidin protects against Helicobacter pylori colonization and the associated gastritis in mice | |
Taniguchi et al. | Tumor-targeting therapy using gene-engineered anaerobic-nonpathogenic Bifidobacterium longum | |
US11318172B2 (en) | Use of genetically engineered bacterium of attenuated Salmonella typhimurium in for treating liver cancer | |
US9816083B2 (en) | Genetically engineered bacterium for treatment of breast cancer, method for constructing the bacterium, and applications thereof | |
Chen et al. | Proteomic screening of anaerobically regulated promoters from Salmonella and its antitumor applications | |
Xiong et al. | The Oxygen-and Iron-Dependent Sigma Factor pvdS of Pseudomonas aevuginosa Is an Important Virulence Factor in Experimental Infective Endocarditis | |
Chen et al. | IL-24 inhibits the growth of hepatoma cells in vivo | |
Liu et al. | Iron-rich conditions induce OmpA and virulence changes of Acinetobacter baumannii | |
Nguyen et al. | Optimized doxycycline-inducible gene expression system for genetic programming of tumor-targeting bacteria | |
Guglielmetti et al. | A Dairy Bacterium Displays I n V itro Probiotic Properties for the Pharyngeal Mucosa by Antagonizing Group A Streptococci and Modulating the Immune Response |