Lajqi et al., 2021 - Google Patents
The role of the pathogen dose and PI3Kγ in immunometabolic reprogramming of microglia for innate immune memoryLajqi et al., 2021
View HTML- Document ID
- 7614664461715812023
- Author
- Lajqi T
- Marx C
- Hudalla H
- Haas F
- Große S
- Wang Z
- Heller R
- Bauer M
- Wetzker R
- Bauer R
- Publication year
- Publication venue
- International journal of molecular sciences
External Links
Snippet
Microglia, the innate immune cells of the CNS, exhibit long-term response changes indicative of innate immune memory (IIM). Our previous studies revealed IIM patterns of microglia with opposing immune phenotypes: trained immunity after a low dose and immune …
- 210000000274 Microglia 0 title abstract description 108
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
- G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving viable micro-organisms
- C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving viable micro-organisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Jakimiec et al. | CDKL5 deficiency disorder—a complex epileptic encephalopathy | |
Lajqi et al. | The role of the pathogen dose and PI3Kγ in immunometabolic reprogramming of microglia for innate immune memory | |
Rudloff et al. | Parsing the IL-37-mediated suppression of inflammasome function | |
Gajęcka et al. | The expression of type-1 and type-2 nitric oxide synthase in selected tissues of the gastrointestinal tract during mixed mycotoxicosis | |
Chuang et al. | Roles of Sestrin2 and ribosomal protein S6 in transient global ischemia-induced hippocampal neuronal injury | |
Erlich et al. | Glycolysis and the pentose phosphate pathway promote LPS-induced NOX2 oxidase-and IFN-β-Dependent inflammation in macrophages | |
Choi et al. | The mechanism of action of ursolic acid as a potential anti-toxoplasmosis agent, and its immunomodulatory effects | |
Wang et al. | Melatonin attenuates spinal cord injury in mice by activating the Nrf2/ARE signaling pathway to inhibit the NLRP3 inflammasome | |
Lajqi et al. | LPS induces opposing memory-like inflammatory responses in mouse bone marrow neutrophils | |
Fernández-Martínez et al. | Inhibition of uterine contractility by thalidomide analogs via phosphodiesterase-4 inhibition and calcium entry blockade | |
Park et al. | Anti-adipogenic effect of neferine in 3T3-L1 cells and primary white adipocytes | |
Schmidt et al. | PI3Kγ mediates microglial proliferation and cell viability via ROS | |
Cichon et al. | Effect of rehabilitation with extremely low frequency electromagnetic field on molecular mechanism of apoptosis in post-stroke patients | |
Giacomini et al. | Timing of treatment with the flavonoid 7, 8-DHF critically impacts on its effects on learning and memory in the Ts65Dn mouse | |
Song et al. | Nicotinamide n-oxide attenuates HSV-1-induced microglial inflammation through sirtuin-1/NF-κB signaling | |
Han et al. | Inhibition of NADPH oxidases prevents the development of osteoarthritis | |
Meloni et al. | Mepazine inhibits RANK-induced osteoclastogenesis independent of its MALT1 inhibitory function | |
González-Candia et al. | Cardioprotective antioxidant and anti-inflammatory mechanisms induced by intermittent hypobaric hypoxia | |
Antinozzi et al. | Sildenafil counteracts the in vitro activation of CXCL-9, CXCL-10 and CXCL-11/CXCR3 axis induced by reactive oxygen species in scleroderma fibroblasts | |
Karalis et al. | Primary cilia dysfunction in neurodevelopmental disorders beyond ciliopathies | |
Chizhikov et al. | Effects of phosphatidylserine source of docosahexaenoic acid on cerebellar development in preterm pigs | |
Neu et al. | DAMPs released from proinflammatory macrophages induce inflammation in cardiomyocytes via activation of TLR4 and TNFR | |
Gutierrez Cruz et al. | Urinary ATP levels are controlled by nucleotidases released from the urothelium in a regulated manner | |
Lee et al. | Chrysophanol mitigates T cell activation by regulating the expression of CD40 ligand in activated T cells | |
Neginskaya et al. | Refractive index imaging reveals that elimination of the ATP synthase C subunit does not prevent the adenine nucleotide translocase-dependent mitochondrial permeability transition |