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Natarajan et al., 2011 - Google Patents

Sustained release of an anti-glaucoma drug: demonstration of efficacy of a liposomal formulation in the rabbit eye

Natarajan et al., 2011

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Document ID
75945581957544503
Author
Natarajan J
Chattopadhyay S
Ang M
Darwitan A
Foo S
Zhen M
Koo M
Wong T
Venkatraman S
Publication year
Publication venue
PloS one

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Snippet

Topical medication remains the first line treatment of glaucoma; however, sustained ocular drug delivery via topical administration is difficult to achieve. Most drugs have poor penetration due to the multiple physiological barriers of the eye and are rapidly cleared if …
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
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    • A61K31/47Quinolines; Isoquinolines
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    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K9/107Emulsions; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
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