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Rodriguez-Meira et al., 2022 - Google Patents

Deciphering TP53 mutant cancer evolution with single-cell multi-omics

Rodriguez-Meira et al., 2022

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Document ID
7518692890425863866
Author
Rodriguez-Meira A
Norfo R
Wen W
Chédeville A
Rahman H
O’Sullivan J
Wang G
Louka E
Kretzschmar W
Paterson A
Brierley C
Martin J
Demeule C
Bashton M
Sousos N
Hamblin A
Guermouche H
Pasquier F
Marzac C
Girodon F
Drummond M
Harrison C
Plo I
Jacobsen S
Psaila B
Thongjuea S
Antony-Debré I
Mead A
Publication year
Publication venue
BiorXiv

External Links

Snippet

TP53 is the most commonly mutated gene in human cancer, typically occurring in association with complex cytogenetics and dismal outcomes. Understanding the genetic and non-genetic determinants of TP53-mutation driven clonal evolution and subsequent …
Continue reading at www.biorxiv.org (HTML) (other versions)

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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Hybridisation probes
    • C12Q1/6883—Hybridisation probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Hybridisation probes for diseases caused by alterations of genetic material for cancer
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
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