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Kapacee et al., 2020 - Google Patents

NUC-1031, use of ProTide technology to circumvent gemcitabine resistance: current status in clinical trials

Kapacee et al., 2020

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Document ID
7514664383341932050
Author
Kapacee Z
Knox J
Palmer D
Blagden S
Lamarca A
Valle J
McNamara M
Publication year
Publication venue
Medical Oncology

External Links

Snippet

Background Resistance to gemcitabine chemotherapy is common in patients with pancreatic ductal adenocarcinoma (PDAC), biliary tract cancer (BTC) and ovarian cancers (OC), conferring poor survival. Use of ProTide technology led to the development of a 'partially …
Continue reading at www.nucana.com (PDF) (other versions)

Classifications

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    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
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