Abad et al., 2008 - Google Patents
Structural determination of estrogen-related receptor γ in the presence of phenol derivative compoundsAbad et al., 2008
View PDF- Document ID
- 7491883006490205945
- Author
- Abad M
- Askari H
- O’Neill J
- Klinger A
- Milligan C
- Lewandowski F
- Springer B
- Spurlino J
- Rentzeperis D
- Publication year
- Publication venue
- The Journal of steroid biochemistry and molecular biology
External Links
Snippet
We screened the ligand-binding domain of estrogen-related receptor (ERR) γ in ThermoFluor®, in an effort to develop chemical tools and decipher the biology of this orphan nuclear receptor. Several ligands were found to stabilize thermodynamically the protein …
- 101710024864 ESRRG 0 title description 7
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
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