[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

Liu et al., 2023 - Google Patents

Inhibition of FAM46/TENT5 activity by BCCIPα adopting a unique fold

Liu et al., 2023

View HTML @Full View
Document ID
7249938089417123309
Author
Liu S
Chen H
Yin Y
Lu D
Gao G
Li J
Bai X
Zhang X
Publication year
Publication venue
Science Advances

External Links

Snippet

The FAM46 (also known as TENT5) proteins are noncanonical poly (A) polymerases (PAPs) implicated in regulating RNA stability. The regulatory mechanisms of FAM46 are poorly understood. Here, we report that the nuclear protein BCCIPα, but not the alternatively …
Continue reading at www.science.org (HTML) (other versions)

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay
    • G01N33/574—Immunoassay; Biospecific binding assay for cancer
    • G01N33/57407—Specifically defined cancers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING; COUNTING
    • G06F—ELECTRICAL DIGITAL DATA PROCESSING
    • G06F19/00—Digital computing or data processing equipment or methods, specially adapted for specific applications
    • G06F19/10—Bioinformatics, i.e. methods or systems for genetic or protein-related data processing in computational molecular biology
    • G06F19/16—Bioinformatics, i.e. methods or systems for genetic or protein-related data processing in computational molecular biology for molecular structure, e.g. structure alignment, structural or functional relations, protein folding, domain topologies, drug targeting using structure data, involving two-dimensional or three-dimensional structures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

Similar Documents

Publication Publication Date Title
Faust et al. Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15
Shen et al. Architecture of the human GATOR1 and GATOR1–Rag GTPases complexes
O'Donnell et al. The architecture of EMC reveals a path for membrane protein insertion
Sampietro et al. Crystal structure of a β-catenin/BCL9/Tcf4 complex
Gadd et al. Structural basis of PROTAC cooperative recognition for selective protein degradation
Kaneko et al. Loops govern SH2 domain specificity by controlling access to binding pockets
Bachmann et al. Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling
Park et al. Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis
Van Weering et al. Molecular basis for SNX‐BAR‐mediated assembly of distinct endosomal sorting tubules
Clapperton et al. Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer
Xing et al. Crystal structure of a full-length β-catenin
Toleman et al. Structural basis of O-GlcNAc recognition by mammalian 14-3-3 proteins
Jiang et al. Substrate and product complexes reveal mechanisms of Hedgehog acylation by HHAT
Sheftic et al. Investigating the human calcineurin interaction network using the πɸLxVP SLiM
Mali et al. Shulin packages axonemal outer dynein arms for ciliary targeting
Chen et al. Mechanisms of leiomodin 2-mediated regulation of actin filament in muscle cells
Smith et al. Single nucleotide polymorphisms alter kinase anchoring and the subcellular targeting of A-kinase anchoring proteins
Liu et al. Inhibition of FAM46/TENT5 activity by BCCIPα adopting a unique fold
Cho et al. GAS41 recognizes diacetylated histone H3 through a bivalent binding mode
Gaetani et al. AIRE-PHD fingers are structural hubs to maintain the integrity of chromatin-associated interactome
Rampler et al. Comprehensive cross-linking mass spectrometry reveals parallel orientation and flexible conformations of plant HOP2–MND1
Menzel et al. 14-3-3 binding creates a memory of kinase action by stabilizing the modified state of phospholamban
Le et al. Structural details of Ufd1 binding to p97 and their functional implications in ER-associated degradation
Kralt et al. Conservation of inner nuclear membrane targeting sequences in mammalian Pom121 and yeast Heh2 membrane proteins
Langousis et al. Structure of the ciliogenesis-associated CPLANE complex