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Ma et al., 2013 - Google Patents

Unconventional origin and hybrid system for construction of pyrrolopyrrole moiety in kosinostatin biosynthesis

Ma et al., 2013

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Document ID
6967734495752793594
Author
Ma H
Zhou Q
Tang Y
Zhang Z
Chen Y
He H
Pan H
Tang M
Gao J
Zhao S
Igarashi Y
Tang G
Publication year
Publication venue
Chemistry & biology

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Kosinostatin (KST), an antitumor antibiotic, features a pyrrolopyrrole moiety spirally jointed to a five-membered ring of an anthraquinone framework glycosylated with a γ-branched octose. By a combination of in silico analysis, genetic characterization, biochemical assay …
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