Kobayashi et al., 2005 - Google Patents
Safety and efficacy of hemoglobin-vesicles and albumin-hemesKobayashi et al., 2005
View PDF- Document ID
- 6929106229513583115
- Author
- Kobayashi K
- Horinouchi H
- Watanabe M
- Izumi Y
- Teramura Y
- Nakagawa A
- Huang Y
- Sou K
- Sakai H
- Komatsu T
- Takeoka S
- Tsuchida E
- Publication year
- Publication venue
- Artificial Oxygen Carrier: Its Front Line
External Links
Snippet
Summary Keio University and Waseda University have worked together on artificial O 2 carrier research for 20 years in close cooperation. Two candidate materials have been selected from the viewpoints of safety, efficacy, and cost performance. One is Hemoglobin …
- 239000000969 carrier 0 abstract description 26
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/38—Albumins
- A61K38/385—Serum albumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/41—Porphyrin- or corrin-ring-containing peptides
- A61K38/42—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
- A61K47/30—Macromolecular compounds
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin, zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
- A61K47/48—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Jansman et al. | Recent and prominent examples of nano-and microarchitectures as hemoglobin-based oxygen carriers | |
| Tsuchida et al. | Artificial oxygen carriers, hemoglobin vesicles and albumin− hemes, based on bioconjugate chemistry | |
| Sakai et al. | Hemoglobin-vesicles as oxygen carriers: influence on phagocytic activity and histopathological changes in reticuloendothelial system | |
| Sakai et al. | Haemoglobin‐vesicles as artificial oxygen carriers: present situation and future visions | |
| Sakai et al. | Subcutaneous microvascular responses to hemodilution with a red cell substitute consisting of polyethyleneglycol‐modified vesicles encapsulating hemoglobin | |
| US9750241B2 (en) | Blood substitute composition and method of use | |
| Sakai et al. | Systemic and microvascular responses to hemorrhagic shock and resuscitation with Hb vesicles | |
| Sakai et al. | Metabolism of hemoglobin-vesicles (artificial oxygen carriers) and their influence on organ functions in a rat model | |
| Sakai et al. | Hemoglobin-vesicles as an artificial oxygen carrier | |
| Matsuhira et al. | Artificial oxygen carriers, from nanometer-to micrometer-sized particles, made of hemoglobin composites substituting for red blood cells | |
| Inayat et al. | Oxygen carriers: a selected review | |
| Sakai | Present situation of the development of cellular-type hemoglobin-based oxygen carrier (hemoglobin-vesicles) | |
| JP5020525B2 (en) | Ligand substitution infusion formulation | |
| EP1683529A1 (en) | Inclusion compound of porphyrin metal complex and albumin | |
| Kobayashi et al. | Safety and efficacy of hemoglobin-vesicles and albumin-hemes | |
| Usuba et al. | Oxygen transport capacity and hemodynamic effect of newly developed artificial blood “Neo Red Cells (NRC)” | |
| Tsuchida et al. | Oxygen infusions (hemoglobin‐vesicles and albumin‐hemes) based on nano‐molecular sciences | |
| KoBAYAsı et al. | Safety and Efficacy of Hemoglobin | |
| WO2001017549A1 (en) | Stably storable oxygen transfusion | |
| JP3085963B2 (en) | Artificial blood | |
| TSUCHIDA | Evaluation of Safety and Efficacy of Hemoglobin-Vesicles and Albumin-Hemes | |
| Ogata et al. | Characteristics of neo red cells, their function and safety: in vivo studies | |
| Sakai et al. | Gas bioengineering using hemoglobin-vesicles for versatile clinical applications | |
| NAKAGAWA et al. | K. KOBAYASHI, H. HORINOUCHI1, M. WATANABE1, Y. IZUMI1, Y. TERAMURA2, A. NAKAGAWA, Y. HUANG2, K. SOU2, H. SAKAI2, T. KOMATSU2, S. TAKEOKA2, and E. TSUCHIDA2 | |
| Sakai et al. | Solution to the problems of acellular hemoglobins by encapsulation and the intrinsic issues of hemoglobin vesicles as a molecular assembly |