Webb, 2024 - Google Patents
The Effects of Nicotine and Opioid Co-use on Dopaminergic and GABAergic Activity in the Ventral Tegmental AreaWebb, 2024
View PDF- Document ID
- 6877055092196598037
- Author
- Webb K
- Publication year
External Links
Snippet
The opioid epidemic has emerged as one of the leading public health concerns of the 21st century. It has been paralleled by a rise in the popularity of e-cigarettes, which has facilitated increased nicotine use among adolescents. Clinical studies have revealed that the co-use of …
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 CN1CCC[C@H]1C1=CC=CN=C1 0 title abstract description 851
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
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