Hibi et al., 2023 - Google Patents
Discovery of type II polyketide synthase-like enzymes for the biosynthesis of cispentacinHibi et al., 2023
View HTML- Document ID
- 6826696548327771421
- Author
- Hibi G
- Shiraishi T
- Umemura T
- Nemoto K
- Ogura Y
- Nishiyama M
- Kuzuyama T
- Publication year
- Publication venue
- Nature Communications
External Links
Snippet
Type II polyketide synthases (PKSs) normally synthesize polycyclic aromatic compounds in nature, and the potential to elaborate further diverse skeletons was recently revealed by the discovery of a polyene subgroup. Here, we show a type II PKS machinery for the …
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 N[C@H]1CCC[C@H]1C(O)=O 0 title abstract description 82
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