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Martens et al., 2024 - Google Patents

Modeling fragment counts improves single-cell ATAC-seq analysis

Martens et al., 2024

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Document ID
6817712075574800131
Author
Martens L
Fischer D
Yépez V
Theis F
Gagneur J
Publication year
Publication venue
Nature Methods

External Links

Snippet

Single-cell ATAC sequencing coverage in regulatory regions is typically binarized as an indicator of open chromatin. Here we show that binarization is an unnecessary step that neither improves goodness of fit, clustering, cell type identification nor batch integration …
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