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Vázquez et al., 2008 - Google Patents

Efficient DNA Binding and Nuclear Uptake by Distamycin Derivatives Conjugated to Octa‐arginine Sequences

Vázquez et al., 2008

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Document ID
6771378800603228637
Author
Vázquez O
Blanco‐Canosa J
Vázquez M
Martínez‐Costas J
Castedo L
Mascareñas J
Publication year
Publication venue
ChemBioChem

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Snippet

Efficient targeting of DNA by designed molecules requires not only careful fine‐tuning of their DNA‐recognition properties, but also appropriate cell internalization of the compounds so that they can reach the cell nucleus in a short period of time. Previous observations in our …
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