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Goppelt et al., 1996 - Google Patents

A mechanism for repression of class II gene transcription through specific binding of NC2 to TBP‐promoter complexes via heterodimeric histone fold domains.

Goppelt et al., 1996

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Document ID
6286796347938887993
Author
Goppelt A
Stelzer G
Lottspeich F
Meisterernst M
Publication year
Publication venue
The EMBO journal

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Snippet

Negative co‐factor 2 (NC2) regulates transcription of the class II genes through binding to TFIID and inhibition of pre‐initiation complex formation. We have isolated and cloned NC2, and investigated the molecular mechanism underlying repression of transcription. NC2 …
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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