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Osteen et al., 2016 - Google Patents

Selective spider toxins reveal a role for the Nav1. 1 channel in mechanical pain

Osteen et al., 2016

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Document ID
6108157245014047352
Author
Osteen J
Herzig V
Gilchrist J
Emrick J
Zhang C
Wang X
Castro J
Garcia-Caraballo S
Grundy L
Rychkov G
Weyer A
Dekan Z
Undheim E
Alewood P
Stucky C
Brierley S
Basbaum A
Bosmans F
King G
Julius D
Publication year
Publication venue
Nature

External Links

Snippet

Voltage-gated sodium (Nav) channels initiate action potentials in most neurons, including primary afferent nerve fibres of the pain pathway. Local anaesthetics block pain through non- specific actions at all Nav channels, but the discovery of selective modulators would facilitate …
Continue reading at www.ncbi.nlm.nih.gov (HTML) (other versions)

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    • G—PHYSICS
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
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