McPherron et al., 1997 - Google Patents
Regulation of skeletal muscle mass in mice by a new TGF-p superfamily memberMcPherron et al., 1997
- Document ID
- 5934039770550372233
- Author
- McPherron A
- Lawler A
- Lee S
- Publication year
- Publication venue
- Nature
External Links
Snippet
The transforming growth factor-β (TGF-β) superfamily encompasses a large group of growth and differentiation factors playing important roles in regulating embryonic development and in maintaining tissue homeostasis in adult animals1. Using degenerate polymerase chain …
- 210000002027 Muscle, Skeletal 0 title abstract description 17
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Hybridisation probes
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/40—Fish
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| McPherron et al. | Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member | |
| Baverstock et al. | A sex-linked enzyme in birds—Z-chromosome conservation but no dosage compensation | |
| Boer et al. | The testis-specific phosphoglycerate kinase gene pgk-2 is a recruited retroposon | |
| Enerbäck et al. | Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese | |
| CA2296434C (en) | Mutations in the myostatin gene cause double-muscling in mammals | |
| US20090318677A1 (en) | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof | |
| US20020150577A1 (en) | Use of antibodies specific for growth differentiation factor-11 | |
| WO1998033887A1 (en) | Growth differentiation factor-8 | |
| US6355782B1 (en) | Hypohidrotic ectodermal dyplasia genes and proteins | |
| WO1998035019A1 (en) | Growth differentiation factor-11 | |
| US8257934B2 (en) | Screening methods using sitosterolemia susceptibility gene (SSG) polypeptides | |
| US7332575B2 (en) | Growth differentiation factor-8 nucleic acid and polypeptide from aquatic species, and transgenic aquatic species | |
| Siracusa et al. | The tight skin (Tsk) mutation in the mouse, a model for human fibrotic diseases, is tightly linked to the β2-microglobulin (B2m) gene on chromosome 2 | |
| JP2003513645A (en) | Melanocortin-3 receptor deficient cells, non-human transgenic animals and methods for selecting compounds that regulate body weight | |
| WO2003102199A1 (en) | New gdf-9 and gdf-9b (bmp-15) sequences for altering mammalian ovarian function and ovulation rate | |
| Georges | When less means more: impact of myostatin in animal breeding | |
| US20100107265A1 (en) | Double-muscling in mammals | |
| US7446239B2 (en) | SCA2 knockout animal and methods of use | |
| US6821750B2 (en) | ABCG8 vectors, host cells, and method of making | |
| NZ528341A (en) | Use of reagents that affect growth differentiation factor-11 (GDF-11) to treat chronic or acute renal disease | |
| Kutzer et al. | Current state of development of genome analysis in livestock | |
| DE10016083A1 (en) | Non-human animal model for growth deficiency and defects in information processing or cognitive function and its use | |
| Markey | Mapping of monogenic and quantitative trait loci using a whole genome scan approach and single nucleotide polymorphism platforms | |
| US6010694A (en) | Fibrillin 1 gene comprising duplication mutation and compositions and kits using the same | |
| US20030118990A1 (en) | Novel estrogen-regulated G protein gamma subunit: compositions and methods of use |