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Freedman et al., 1997 - Google Patents

A genetic approach to mapping the p53 binding site in the MDM2 protein

Freedman et al., 1997

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Document ID
5640000919626212522
Author
Freedman D
Epstein C
Roth J
Levine A
Publication year
Publication venue
Molecular Medicine

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Background The MDM2 oncoprotein binds to the tumor suppressor p53 and inhibits its anti- oncogenic functions. Materials and Methods To determine the amino acids of MDM2 that are critical for binding to p53, a modified two-hybrid screen was performed in yeast. Site-directed …
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