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Brough et al., 1985 - Google Patents

Restricted changes in the adenovirus DNA-binding protein that lead to extended host range or temperature-sensitive phenotypes

Brough et al., 1985

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Document ID
5427452091151667978
Author
Brough D
Rice S
Sell S
Klessig D
Publication year
Publication venue
Journal of virology

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Snippet

Human adenovirus fails to multiply efficiently in monkey cells owing to a block to late viral gene expression. Ad2hr400 through Ad2hr403 are a set of host range (hr) mutants which were selected for their ability to readily grow in these cells at 37 degrees C. The mutations …
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