Wikberg et al., 2000 - Google Patents
New aspects on the melanocortins and their receptorsWikberg et al., 2000
- Document ID
- 4998962391237736528
- Author
- Wikberg J
- Muceniece R
- Mandrika I
- Prusis P
- Lindblom J
- Post C
- Skottner A
- Publication year
- Publication venue
- Pharmacological research
External Links
Snippet
Knowledge of melanocortins and their receptors has increased tremendously over the last few years. The cloning of five melanocortin receptors, and the discovery of two endogenous antagonists for these receptors, agouti and agouti-related peptide, have sparked intense …
- 239000002865 melanocortin 0 title abstract description 29
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/68—Melanocyte-stimulating hormone [MSH]
- C07K14/685—Melanocyte-stimulating hormone [MSH] alpha-Melanotropin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/695—Corticotropin [ACTH]
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Wikberg et al. | New aspects on the melanocortins and their receptors | |
Wolf Horrell et al. | Melanocortin 1 receptor: structure, function, and regulation | |
Abdel-Malek | Melanocortin receptors: their functions and regulation by physiological agonists and antagonists | |
Wikberg | Melanocortin receptors: perspectives for novel drugs | |
Haskell-Luevano et al. | Agouti-related protein functions as an inverse agonist at a constitutively active brain melanocortin-4 receptor | |
Schiöth | The physiological role of melanocortin receptors | |
Abdel-Malek et al. | Melanocortins and the melanocortin 1 receptor, moving translationally towards melanoma prevention | |
Cerdá-Reverter et al. | Fish melanocortin system | |
Millington | Proopiomelanocortin (POMC): the cutaneous roles of its melanocortin products and receptors | |
Berruien et al. | Emerging roles of melanocortin receptor accessory proteins (MRAP and MRAP2) in physiology and pathophysiology | |
Voisey et al. | Melanocortins and their receptors and antagonists | |
Abdel‐malek et al. | The melanocortin‐1 receptor and human pigmentation | |
Cone | The melanocortin-4 receptor | |
Mountjoy et al. | Obesity, diabetes and functions for proopiomelanocortin-derived peptides | |
MacNeil et al. | The role of melanocortins in body weight regulation: opportunities for the treatment of obesity | |
Solomon | POMC‐derived peptides and their biological action | |
ABDEL‐MALEK et al. | The melanocortin‐1 receptor is a key regulator of human cutaneous pigmentation | |
Stütz et al. | The Agouti-related protein and its role in energy homeostasis | |
Thody et al. | Does α‐MSH have a role in regulating skin pigmentation in humans? | |
Carroll et al. | Mouse models of obesity | |
Marsh et al. | Effects of neuropeptide Y deficiency on hypothalamic agouti-related protein expression and responsiveness to melanocortin analogues | |
Norman et al. | ACTH and α-MSH inhibit leptin expression and secretion in 3T3-L1 adipocytes: model for a central–peripheral melanocortin-leptin pathway | |
Boswell et al. | Recent developments in our understanding of the avian melanocortin system: its involvement in the regulation of pigmentation and energy homeostasis | |
Irani et al. | Progress in the development of melanocortin receptor selective ligands | |
Millington et al. | Differential effects of α-, β-and γ2-melanocyte-stimulating hormones on hypothalamic neuronal activation and feeding in the fasted rat |