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Moroishi et al., 2016 - Google Patents

The Hippo pathway kinases LATS1/2 suppress cancer immunity

Moroishi et al., 2016

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Document ID
4866946901515427467
Author
Moroishi T
Hayashi T
Pan W
Fujita Y
Holt M
Qin J
Carson D
Guan K
Publication year
Publication venue
Cell

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Poorly immunogenic tumor cells evade host immunity and grow even in the presence of an intact immune system, but the complex mechanisms regulating tumor immunogenicity have not been elucidated. Here, we discovered an unexpected role of the Hippo pathway in …
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
    • C12N5/0602Vertebrate cells
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