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Kweon et al., 2019 - Google Patents

An adversarial DNA N6-methyladenine-sensor network preserves polycomb silencing

Kweon et al., 2019

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Document ID
4727751690222291271
Author
Kweon S
Chen Y
Moon E
Kvederaviciutė K
Klimasauskas S
Feldman D
Publication year
Publication venue
Molecular cell

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Snippet

Adenine N6 methylation in DNA (6mA) is widespread among bacteria and phage and is detected in mammalian genomes, where its function is largely unexplored. Here we show that 6mA deposition and removal are catalyzed by the Mettl4 methyltransferase and Alkbh4 …
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
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