[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

Farmer et al., 1988 - Google Patents

Liposome-encapsulated hemoglobin: oxygen binding properties and respiratory function

Farmer et al., 1988

Document ID
4694226478837700810
Author
Farmer M
Rudolph A
Vandegriff K
Hayre M
Bayne S
Johnson S
Publication year
Publication venue
Biomaterials, Artificial Cells and Artificial Organs

External Links

Snippet

Lipid bilayer membranes have been used to encapsulate hemoglobin and organic phosphates, resulting in a synthetic red cell with oxygen-binding properties very similar to red blood cells (RBCs). In addition to the oxygen-binding parameters, we report here an …
Continue reading at www.tandfonline.com (other versions)

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells

Similar Documents

Publication Publication Date Title
Farmer et al. Liposome-encapsulated hemoglobin: oxygen binding properties and respiratory function
US4776991A (en) Scaled-up production of liposome-encapsulated hemoglobin
US4911929A (en) Blood substitute comprising liposome-encapsulated hemoglobin
Farmer et al. [18] Liposome-encapsulated hemoglobin as an artificial oxygen-carrying system
CA2117528C (en) Facilitated oxygen delivery in conjunction with hemodilution
US4133874A (en) Lipid encapsulated hemoglobin cells
JPH11507378A (en) Hemodilution method simplified by monitoring oxygen saturation status (OXGENATION STATUS)
Ogata et al. Development of neo red cells (NRC) with the enyzmatic reduction system of methemoglobin
Farmer et al. Liposome-encapsulated hemoglobin: a synthetic red cell
Jopski et al. Preparation of hemoglobin-containing liposomes using octyl glucoside and octyltetraoxyethylene
Takahashi Characterization of neo red cells (NRCs), their function and safety in vivo tests
Vidal-Naquet et al. Ltposome-Encapsulated Hemoglobin as an Artificial Red Blood Cell: Characterization and Scale-Up
Usuba et al. Oxygen transport capacity and hemodynamic effect of newly developed artificial blood “Neo Red Cells (NRC)”
Wang et al. Modulation of oxygen‐carrying capacity of artificial red cells
Zheng et al. Liposome-encapsulated hemoglobin: a red blood cell substitute
Usuba et al. Effect of neo red cells on the canine hemorrhagic shock model
EP0687463A1 (en) Hemoglobin-encapsulated liposome
Deshpande et al. Liposome-encapsulated hemoglobin using film hydration processing to form artificial red blood cells
JPS62178521A (en) Liposome containing hemoglobin
Davis et al. Artificial red cells with crosslinked hemoglobin membranes
Johnson et al. LIPOSOME-ENCAPSULATED HEMOGLOBIN: A SYNTHETIC RED CELL
Gersonde et al. Modification of the oxygen affinity of intracellular haemoglobin by incorporation of polyphosphates into intact red blood cells and enhanced O2 release in the capillary system
JPH075477B2 (en) Hemoglobin-containing liposome and method for producing the same
Chang et al. Blood substitutes based on modified hemoglobin and fluorochemicals
MILLER Synthetic Red Blood Cells from Lipid Encapsulated Hemoglobin