[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

Borrello et al., 1996 - Google Patents

The full oncogenic activity of Ret/ptc2 depends on tyrosine 539, a docking site for phospholipase Cγ

Borrello et al., 1996

View PDF
Document ID
4531296796326724495
Author
Borrello M
Alberti L
Arighi E
Bongarzone I
Battistini C
Bardelli A
Pasini B
Piutti C
Rizzetti M
Mondellini P
Radice M
Pierotti M
Publication year
Publication venue
Molecular and cellular biology

External Links

Snippet

RET/PTC oncogenes, generated by chromosomal rearrangements in papillary thyroid carcinomas, are constitutively activated versions of proto-RET, a gene coding for a receptor- type tyrosine kinase (TK) whose ligand is still unknown. RET/PTCs encode fusion proteins in …
Continue reading at www.ncbi.nlm.nih.gov (PDF) (other versions)

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Similar Documents

Publication Publication Date Title
Borrello et al. The full oncogenic activity of Ret/ptc2 depends on tyrosine 539, a docking site for phospholipase Cγ
Mori et al. Identification of two juxtamembrane autophosphorylation sites in the PDGF beta‐receptor; involvement in the interaction with Src family tyrosine kinases.
Honegger et al. Evidence for epidermal growth factor (EGF)-induced intermolecular autophosphorylation of the EGF receptors in living cells
Lev et al. Interkinase domain of kit contains the binding site for phosphatidylinositol 3'kinase.
Souchelnytskyi et al. Phosphorylation of Ser165 in TGF‐beta type I receptor modulates TGF‐beta1‐induced cellular responses.
US5916755A (en) Methods of characterizing ligands for the erbB-3 receptor, methods of influencing erbB-3 activities and methods of diagnosing erbB-3-related neoplasm
Pronk et al. Involvement of She in insulin-and epidermal growth factor-induced activation of p21 ras
Bar-Sagi et al. SH3 domains direct cellular localization of signaling molecules
Rameh et al. Phosphatidylinositol (3, 4, 5) P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins
Van Der Geer et al. Identification of residues that control specific binding of the Shc phosphotyrosine-binding domain to phosphotyrosine sites.
Stephens et al. A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits
Maroun et al. The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase
Hu et al. Binding of NCK to SOS and activation of ras-dependent gene expression
Cicchetti et al. 3BP‐1, an SH3 domain binding protein, has GAP activity for Rac and inhibits growth factor‐induced membrane ruffling in fibroblasts.
Cooper et al. In vivo binding properties of SH2 domains from GTPase-activating protein and phosphatidylinositol 3-kinase
Oishi et al. Identification and characterization of PKNβ, a novel isoform of protein kinase PKN: expression and arachidonic acid dependency are different from those of PKNα
US7148002B2 (en) Nucleic acids and polypeptides related to a guanine exchange factor of Rho GTPase
Zhang et al. Molecular basis of distinct interactions between Dok1 PTB domain and tyrosine-phosphorylated EGF receptor
Zhang et al. Absence of autophosphorylation site Y882 in the p185neu oncogene product correlates with a reduction of transforming potential
Summy et al. Specificity in signaling by c-Yes
Rosorius et al. Characterization of phosphorylation sites in the cytoplasmic domain of the 300 kDa mannose-6-phosphate receptor
Hooshmand-Rad et al. Platelet-derived growth factor-mediated signaling through the Shb adaptor protein: effects on cytoskeletal organization
Kim et al. Actinomycin D as a novel SH2 domain ligand inhibits Shc/Grb2 interaction in B104-1-1 (neu*-transformed NIH3T3) and SAA (hEGFR-overexpressed NIH3T3) cells
Shearman et al. Phosphatidylinositol 3′‐kinase associates with p145c‐kit as part of a cell type characteristic multimeric signalling complex.
EP0996638A2 (en) Methods and compositions for treating abnormal cell growth related to unwanted guanine nucleotide exchange factor activity