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MicroRNAs delivered by extracellular vesicles: an emerging resistance mechanism for breast cancer

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  • Published:
Tumor Biology

Abstract

Resistance to chemotherapy and endocrine therapy as well as targeted drugs is a major problem in treatment of breast cancer. Over the last decades, emerging studies have revealed that extracellular vesicles, which are chronically released by breast cancer cells and surrounding stromal cells, influence the action of most commonly used therapeutics. Such modulatory effects have been related to the transport of biologically active molecules including proteins and functional microRNAs. In this review, we highlight recent studies regarding extracellular vesicle-mediated microRNA delivery in formatting drug resistance. We also suggest the use of extracellular vesicles as a promising method in antiresistance treatment.

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Abbreviations

EV:

Extracellular vesicle

BCa:

Breast cancer

miRNA:

MicroRNA

mRNA:

Message RNA

P-gp:

P-glycoprotein

mdr 1:

Multidrug resistance 1

PDGF:

Platelet-derived growth factor

EGFR:

Epidermal growth factor receptor

ECs:

Endothelial cells

VEGF:

Vascular endothelial growth factor

TLR:

Toll-like receptor

TAMs:

Tumor-associated macrophages

DCs:

Dendritic cells

siRNA:

Small interfering RNA

EGF:

Epidermal growth factor

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Acknowledgments

We would like to acknowledge the funding body for supporting this work: the National Natural Science Foundation of China provided to Jin-hai Tang and Jian-hua Zhao. We also thank Jian-Zhong Wu for his discussions and help in our manuscript.

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Authors and Affiliations

  1. The Fourth Clinical School of Nanjing Medical University, Nanjing, 210029, China

    Wei-xian Chen, Meng Pan, Meng-meng Lv & Zhou Luo

  2. Department of General Surgery, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, 42 Baiziting, Nanjing, 210009, China

    Wei-xian Chen, Ming-hua Ji, Qing Hu, Meng-meng Lv, Zhou Luo & Jin-hai Tang

  3. Center of Clinical Laboratory, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, 42 Baiziting, Nanjing, 210009, China

    Shan-liang Zhong & Jian-hua Zhao

  4. Graduate School, Xuzhou Medical College, Xuzhou, 221002, China

    Qing Hu

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  1. Wei-xian Chen
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Chen, Wx., Zhong, Sl., Ji, Mh. et al. MicroRNAs delivered by extracellular vesicles: an emerging resistance mechanism for breast cancer. Tumor Biol. 35, 2883–2892 (2014). https://doi.org/10.1007/s13277-013-1417-4

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