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Functional Crosstalk Between Cell-Surface and Intracellular Channels Mediated by Junctophilins Essential for Neuronal Functions

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Abstract

Junctophilins (JPs) contribute to the formation of junctional membrane complexes between the plasma membrane and the endoplasmic/sarcoplasmic reticulum, and provide a structural platform for channel communication during excitation–contraction coupling in muscle cells. In the brain, two neuronal JP subtypes are widely expressed in neurons. Recent studies have defined the essential role of neural JPs in the communication between cell-surface and intracellular channels, which modulates the excitability and synaptic plasticity of neurons in the cerebellum and hippocampus.

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Authors and Affiliations

  1. Department of Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

    Sho Kakizawa & Masamitsu Iino

  2. Department of Anatomy and Neurobiology, Graduate School of Medicine, Nagasaki University, Nagasaki, Japan

    Sho Kakizawa

  3. Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan

    Shigeki Moriguchi

  4. Department of Biological Chemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Kyoto, 606-8501, Japan

    Atsushi Ikeda & Hiroshi Takeshima

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  1. Sho Kakizawa
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  2. Shigeki Moriguchi
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  3. Atsushi Ikeda
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  4. Masamitsu Iino
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  5. Hiroshi Takeshima
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Correspondence to Hiroshi Takeshima.

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Kakizawa, S., Moriguchi, S., Ikeda, A. et al. Functional Crosstalk Between Cell-Surface and Intracellular Channels Mediated by Junctophilins Essential for Neuronal Functions. Cerebellum 7, 385–391 (2008). https://doi.org/10.1007/s12311-008-0040-1

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