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Changes in the Level of Circulating hsa-miR-297 and hsa-miR-19b-3p miRNA Are Associated with Generalization of Prostate Cancer

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Bulletin of Experimental Biology and Medicine Aims and scope

We performed diagnostic classification of plasma specimens from patients with non-metastatic and metastatic prostate cancer based on pairs of miRNA that have no individual diagnostic significance. Of 230 miRNA detected in plasma specimens, 3 pairs were diagnostically significant. The miRNA pair hsa-miR-19b-3p and hsa-miR-297 demonstrated highest sensitivity and specificity. Among common target genes of these miRNA, CFL2 gene associated with cell mobility was detected.

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Authors and Affiliations

  1. BioClinicum Research and Development Centre, Moscow, Russia

    A. I. Osip’yants, E. N. Knyazev, A. V. Galatenko & V. V. Galatenko

  2. P.A. Herzen Moscow Oncology Research Institute, Ministry of Health of the Russian Federation, Moscow, Russia

    A. I. Osip’yants, E. N. Knyazev, K. M. Nyushko, M. Yu. Shkurnikov & B. Ya. Alekseev

Authors
  1. A. I. Osip’yants
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  2. E. N. Knyazev
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  3. A. V. Galatenko
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  4. K. M. Nyushko
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  5. V. V. Galatenko
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  6. M. Yu. Shkurnikov
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  7. B. Ya. Alekseev
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Corresponding author

Correspondence to M. Yu. Shkurnikov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 162, No. 9, pp. 366-369, September, 2016

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Osip’yants, A.I., Knyazev, E.N., Galatenko, A.V. et al. Changes in the Level of Circulating hsa-miR-297 and hsa-miR-19b-3p miRNA Are Associated with Generalization of Prostate Cancer. Bull Exp Biol Med 162, 379–382 (2017). https://doi.org/10.1007/s10517-017-3620-6

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  • DOI: https://doi.org/10.1007/s10517-017-3620-6

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