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Biotechnological production and application of ganoderic acids

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Abstract

Ganoderic acids (GAs), a kind of highly oxygenated lanostane-type triterpenoids, are important bioactive constituents of the famous medicinal mushroom Ganoderma lucidum. They have received wide attention in recent years due to extraordinarily pharmacological functions. Submerged fermentation of G. lucidum is viewed as a promising technology for production of GAs, and substantial efforts have been devoted to process development for enhancing GA production in the last decade. This article reviews recent publication about fermentative production of GAs and their potential applications, especially the progresses toward manipulation of fermentation conditions and bioprocessing strategies are summarized. The biosynthetic pathway of GAs is also outlined.

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Acknowledgment

Financial support from the National Natural Science Foundation of China (NSFC project nos. 20776084 and 30821005), the National High Technology R&D Program (863 project no. 2007AA021506), Shanghai Science and Technology Commission (project no. 08DZ1971900), and the Shanghai Leading Academic Discipline Project (project nos. B203 and B505) is gratefully acknowledged.

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  1. Key Laboratory of Microbial Metabolism (Ministry of Education), School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dong-Chuan Road, Shanghai, 200240, China

    Jun-Wei Xu, Wei Zhao & Jian-Jiang Zhong

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  1. Jun-Wei Xu
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  2. Wei Zhao
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Correspondence to Jian-Jiang Zhong.

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Xu, JW., Zhao, W. & Zhong, JJ. Biotechnological production and application of ganoderic acids. Appl Microbiol Biotechnol 87, 457–466 (2010). https://doi.org/10.1007/s00253-010-2576-5

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