Thermoregulation in the diabetic-obese (db/db) mouse

• Abraham, R. R., Dade, E., Elliot, J., Hems, D. A.: Hormonal control of intermediary metabolism in obese hyperglycemic mice. II. Level of plasma free fatty acid and immunoreactive insulin and liver glycogen. Diabetes20, 535–541 (1971)

  Google Scholar 

• Allan, J. A., Yen, T. T.: Lipolytic response of “diabetic” mice (db/db) to isoproterenol and propranolol in vivo. Experientia32, 836–837 (1976)

  Google Scholar 

• Alonso, L. G., Maren, T. H.: Effect of food restriction on body composition of hereditary obese mice. Am. J. Physiol.183, 284–290 (1955)

  Google Scholar 

• Bray, G. A., York, D. A.: Genetically transmitted obesity in rodents. Physiol. Rev.51, 598–646 (1971)

  Google Scholar 

• Bray, G. A., York, D. A., Yukimura, Y.: Activity of (Na⁺+K⁺)-ATPase in the liver of animals with experimental obesity. Life Sci.22, 1637–1642 (1978)

  Google Scholar 

• Carnie, J. A., Smith, D. G.: Release of fatty acids from adipose tissue in genetically obese (ob/ob) mice. FEBS Lett.90, 132–134 (1978)

  Google Scholar 

• Chlouverakis, C.: Induction of obesity in obese-hyperglycaemic mice on normal food intake. Experientia26, 1262–1263 (1970)

  Google Scholar 

• Coleman, D. L.: Diabetes and obesity: thrifty mutants? Nutr. Rev.36, 129–132 (1978)

  Google Scholar 

• Coleman, D. L., Hummel, K. P.: Hyperinsulinemia in preweaning diabetes (db) mice. Diabetologia10, 607–610 (1974)

  Google Scholar 

• Cooper, K. E.: The body temperature “set-point” in fever. In: Essays on temperature regulation (J. Bligh and R. E. Moore, eds.). Amsterdam: North Holland 1972

  Google Scholar 

• Cox, J. E., Powley, T. L.: Development of obesity in diabetic mice pair-fed with lean siblings. J. Comp. Physiol. Psychol.91, 347–358 (1977)

  Google Scholar 

• Falconer, D. S., Isaacson, J. H.: Adipose, a new inherited obesity of the mouse. J. Hered.50, 290–292 (1959)

  Google Scholar 

• Herberg, L., Coleman, D. L.: Laboratory animals exhibiting obesity and diabetes syndromes. Metabolism26, 59–99 (1977)

  Google Scholar 

• Himms-Hagen, J., Desautels, M.: A mitochondrial defect in brown adipose tissue of the obese (ob/ob) mouse: reduced binding of purine nucleotides and a failure to respond to cold by an increase in binding. Biochem. Biophys. Res. Commun.83, 628–634 (1978)

  Google Scholar 

• Hummel, K. P., Dickie, M. M., Coleman, D. L.: Diabetes, a new mutation in the mouse. Science153, 1127–1128 (1966)

  Google Scholar 

• Hummel, K. P., Coleman, D. L. Lane, P. W.: The influence of genetic background on expression of mutations at the diabetes locus in the mouse. 1. C57BL/KsJ and C57BL/6J strains. Biochem. Genet.7, 1–13 (1972)

  Google Scholar 

• James, W. P. T., Trayhurn, P.: An integrated view of the metabolic and genetic basis of obesity. Lancet1976II, 770–773

• Jansky, L.: Non-shivering thermogenesis and its thermoregulatory significance. Biol. Rev.48, 85–132 (1973)

  Google Scholar 

• Le Marchand-Brustel, Y., Jeanrenaud, B.: Pre-and post weanling studies on development of obesity in mdb/mdb mice. Am J. Physiol.234, E568-E574 (1978)

  Google Scholar 

• Lin, M. H., Romsos, D. R., Akera, T., Leveille, G. A.: Na⁺, K⁺-ATPase enzyme units in skeletal muscle from lean and obese mice. Biochem. Biophys. Res. Commun.80, 398–404 (1978)

  Google Scholar 

• Mitchell, D., Atkins, A. R., Wyndham, C. H.: Mathematical and physical models of thermoregulation. In: Essays on temperature regulation (J. Bligh and R. E. Moore, eds.). Amsterdam: North Holland 1972

  Google Scholar 

• Neel, J. V.: Diabetes mellitus: a “thrifty” genotype rendered detrimental by “progress”? Am. J. Hum. Genet.14, 353–362 (1962)

  Google Scholar 

• Stock, M. J.: An automatic, closed-circuit oxygen consumption apparatus for small animals. J. Appl. Physiol.39, 849–850 (1975)

  Google Scholar 

• Trayhurn, P., James, W. P. T.: Thermoregulation and non-shivering thermogenesis in the genetically obese (ob/ob) mouse. Pflügers Arch.373, 189–193 (1978)

  Google Scholar 

• Trayhurn, P., Thurlby, P. L., Woodward, C. J. H., James, W. P. T.: Thermoregulation in genetically obese rodents: the relationship to metabolic efficiency. In: Genetic models of obesity in laboratory animals (M. F. W. Festing, ed.). London: Macmillans 1979

  Google Scholar 

• Yen, T. T., Fuller, R. W., Pearson, D. V.: The response of “obese” (ob/ob) and “diabetic” (db/db) mice to treatments that influence body temperature. Comp. Biochem. Physiol.49A, 377–385 (1974)

  Google Scholar 

• York, D. A., Bray, G. A., Yukimura, Y.: An enzymatic defect in the obese (ob/ob) mouse: Loss of thyroid induced sodium — and potassium — dependent adenosinetriphosphatase. Proc. Natl. Acad. Sci. USA75, 477–481 (1978)

  Google Scholar 

• Zucker, L. M.: Efficiency of energy utilization by the Zucker hereditarily obese rat “fatty”. Proc. Soc. Exp. Biol. Med.148, 498–500 (1975)

  Google Scholar 

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