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Use of animal models in diagnosis and treatment of renal cell carcinoma

An overview

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Summary

This paper gives an overview of animal models available for the study of human renal cell carcinoma. Animal model systems can be divided into four categories: drug-induced tumors, virus-induced tumors, spontaneous tumors and human tumors transplanted into nude mice. Animal models have been used for improvement of diagnostic and therapeutic procedures. New markers for the diagnosis of more aggressive tumors can, for instance, be found by comparing metastatic with non-metastatic variants of the same primary tumor. Since advanced human renal cell carcinoma is refractory to chemotherapeutic agents, most therapeutic studies on animal models are immunotherapy studies. Combination treatment of biological-response modifiers such as interferon and tumor necrosis factor, with hyperthermia, bispecific monoclonal antibodies and high-energy shock waves, show promising results. Gene therapy will open new therapeutic possibilities.

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References

  1. Bailey MJ, Jones AJ, Shorthouse AJ, Raghaven D, Selby P, Gibbs J, Peckham MJ (1984) Limitations of the human tumour xenograft system in individual patient drug sensitivity testing. Br J Cancer 50:721–724

    Google Scholar 

  2. Bear A, Clayman RV, Elbers J, Limas C, Wang N, Stone K, Gebhard R, Prigge W, Palmer J (1987) Characterization of two human cell lines (TK-10, TK-164) of renal cell cancer. Cancer Res 47:3856–3862

    Google Scholar 

  3. Beckley S (1980) Viral models of renal adenocarcinoma. In: Sufrin G, Beckley SA (eds) Renal adenocarcinoma. Technical report series, vol 49, UICC, Geneva, pp 29–43

    Google Scholar 

  4. Beniers AJMC, Moorselaar RJA van, Peelen WP, Debruyne FMJ, Schalken JA (1991) Differential sensitivity of renal cell carcinoma xenografts towards therapy with interferon-alpha, interferon-gamma, tumor necrosis factor and their combinations. Urol Res 19:91–98

    Google Scholar 

  5. Burgers JK, Marshall FF, Isaacs JT (1989) Enhanced anti-tumor effects of recombinant human tumor necrosis factor plus VP-16 on metastatic renal cell carcinoma in a xenograft model. J Urol 142:160–164

    Google Scholar 

  6. Bussemakers MJG, Debruyne FMJ, Ven WJM van de, Schalken JA (1991) Identification of HMG-I(Y) as potential progression marker for prostate cancer by differential hybridization analysis. Cancer Res 51:606–611

    Google Scholar 

  7. Chiou RK (1989) Biodistribution and radioimmunoscintigraphy studies of renal cell carcinoma using tumor-preferential monoclonal antibodies and F (ab')2 fragments. J Urol 142:1584–1588

    Google Scholar 

  8. Chiou RK, Vessella RL, Limas C, Shafer RB, Elson MK, Arfman EW, Lange PH (1988) Monoclonal antibody-targeted radiotherapy of renal cell carcinoma using a nude mouse model. Cancer 61:1766–1775

    Google Scholar 

  9. Claude A (1962) A spontaneous transplantable renal carcinoma of the mouse. Electron microscope study of the cells and of an associated virus-like particle. J Ultrastruct Res 6:1–18

    Google Scholar 

  10. Clayman RV, Figenshau RS, Bear A, Limas (1985) Transplantation of human renal carcinomas into athymic mice. Cancer Res 45:2650–2653

    Google Scholar 

  11. Coffey DS, Isaacs JT, Weisman RM (1979) Animal models for study of prostatic cancer. In: Murphy GP (ed) Prostatic cancer. PSG, Littleton, Mass, pp 89–109

    Google Scholar 

  12. Davey FR, Moloney (1970) Postmortem observations on Fischer rats with leukemia and other disorders. Lab Invest 23:327–334

    Google Scholar 

  13. Dijk J van, Warnaar SO, Eendenburg JDH van, Thienpont M, Braakman E, Boot JHA, Fleuren GJ, Bolhuis RLH (1989) Induction of tumor-cell lysis by bi-specific monoclonal antibodies recognizing renal-cell carcinoma and CD3 antigen. Int J Cancer 43:344–349

    Google Scholar 

  14. Ebert T, Bander NH, Finstad CL, Ramsawak RD, Old JL (1990) Establishment and characterization of human renal cancer and normal kidney cell lines. Cancer Res 50:5531–5536

    Google Scholar 

  15. Eker R, Mossige J (1961) A dominant gene for renal adenomas in the rat. Nature 189:858–859

    Google Scholar 

  16. Ertürk E, Cohen SM, Bryan GT (1970) Induction, histogenesis, and isotransplantability of renal tumors induced by formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl]-hydrazide in rats. Cancer Res 30:2098–2106

    Google Scholar 

  17. Freed SZ, Halperin JP, Gordon M (1977) Idiopathic regression of metastases from renal cell carcinoma. J Urol 118:538–542

    Google Scholar 

  18. Gonzalez A, Oberley TD, Li JJ (1989) Morphological and immunohistochemical studies of the estrogen-induced Syrian hamster renal tumor: probable cell or origin. Cancer Res 49:1020–1028

    Google Scholar 

  19. Hagemeijer A, Hoehn W, Smit EME (1979) Cytogenetic analysis of human renal cell carcinoma cell lines of common origin (NC65). Cancer Res 39:4662–4667

    Google Scholar 

  20. Hard GC, Butler WH (1971) Ultrastructural aspects of renal adenocarcinoma induced in the rat by dimethylnitrosamine. Cancer Res 31:366–372

    Google Scholar 

  21. Harris DT (1983) Hormonal therapy and chemotherapy of renal-cell carcinoma. Semin Oncol 10:422–430

    Google Scholar 

  22. Hashimura T, Tubbs RR, Connelly R, Caulfield MJ, Trindade CS, McMahon JT, Galetti TP, Edinger M, Sandberg AA, Cin PD, Sait SJ, Pontes JE (1989) Characterization of two cell lines with distinct phenotypes and genotypes established from a patient with renal cell carcinoma. Cancer Res 49:7064–7071

    Google Scholar 

  23. Hewitt HB (1978) The choice of animal tumors for experimental studies of cancer therapy. Adv Cancer Res 27:149–200

    Google Scholar 

  24. Kallman RF, Denekamp J, Hill RP, Kummermehr J (1985) The use of rodent tumors in experimental cancer therapy. Conclusions and recommendations from an international workshop. Cancer Res 45:6541–6545

    Google Scholar 

  25. Karthaus HFM, Feitz WFJ, Meijden APM vd, Schalken JA, Beck JLM, Hendriks BTh, Jap PHK, Vooijs GP, Debruyne FMJ, Ramaekers FCS (1987) Multidisciplinary evaluation of rat renal cell carcinoma. In Vivo 1:335–342

    Google Scholar 

  26. Kasid A, Morecki S, Aebersold P, Cornetta K, Culver K, Freeman S, Director E, Lotze MT, Blaese RM, Anderson WF, Rosenberg SA (1990) Human gene transfer: characterization of human infiltrating lymphocytes as vehicles for retroviral-mediated gene transfer in man. Proc Natl Acad Sci USA 87:473–477

    Google Scholar 

  27. Katsuoka Y, Baba S, Hata M, Tazaki H (1976) Transplantation of human renal cell carcinoma to the nude mice: as an intermediate of in vivo and in vitro studies. J Urol 115:373–376

    Google Scholar 

  28. Kernion JB de, Ramming KP, Smith RB (1978) The natural history of metastatic renal cell carcinoma: a computer analysis. J Urol 120:148–152

    CAS  PubMed  Google Scholar 

  29. Kernion JB de, Mukamel E, Ritchie AWS, Blyth B, Hannah J, Bohman R (1989) Prognostic significance of the DNA content of renal carcinoma. Cancer 64:1669–1673

    Google Scholar 

  30. Kerr LA, Huntoon CJ, Nelson H, Leibson PJ, Segal D, Donohue JH, Vessella R, Warnaar S, Bolhuis R, McKean DJ, Zincke H (1990) Immunotherapy of renal cell carcinoma using the G250/OKT3 bispecific antibody. J Urol 143:321A

    Google Scholar 

  31. Knöfel WT, Otto U, Baisch H, Klöppel G (1987) Stability of human renal cell carcinomas during long term serial transplantation into nude mice: histopathology, nuclear grade, mitotic rate, and DNA content in thirty tumors. Cancer Res 47:221–224

    Google Scholar 

  32. Kovi J, Kovi E, Morris HP (1977) Progression of two of the three transplantable Morris renal tumors: study of histology, ultrastructure and chromosome banding patterns. Adv Enzyme Reg 16:319–334

    Google Scholar 

  33. Mace KF, Hornung RL, Wiltrout RH, Young HA (1990) Correlation between in vivo induction of cytokine gene expression by flavone acetic acid and strict dose dependency and therapeutic efficacy against murine renal cancer. Cancer Res 50:1742–1747

    Google Scholar 

  34. Matsuda M, Osafune M, Nakano E, Kotake T, Sonoda T, Watanabe S, Hada T, Okochi T, Higashino K, Yamamura Y, Abe T (1979) Characterization of an established cell line from human renal carcinoma. Cancer Res 39:4694–4699

    Google Scholar 

  35. Moorselaar RJA van, Beniers AJMC, Hendriks BT, Debruyne FMJ, Schalken JA (1990) Antiproliferative effects of adriamycin and tumor necrosis factor alpha in a rat renal cell tumor model system. J Urol 143:387A

    Google Scholar 

  36. Moorselaar RJA van, Beniers AJMC, Hendriks BT, Meide PH van der, Schellekens H, Debruyne FMJ, Schalken JA (1990) In vivo antiproliferative effects of gamma-interferon and tumor necrosis factor alpha in a rat renal cell carcinoma model system. J Urol 143:1247–1251

    Google Scholar 

  37. Murphy GP, Hrushesky WJ (1973) A murine renal cell carcinoma. J Natl Cancer Inst 50:1013–1025

    Google Scholar 

  38. Murphy GP, Johnston GS, Melby EC (1967) Comparative aspects of experimentally induced and spontaneously observed renal tumors. J Urol 97:965–972

    Google Scholar 

  39. Naito S, Eschenbach AC von, Giavazzi R, Fidler IJ (1986) Growth and metastasis of tumor cells isolated from a human renal cell carcinoma implanted into different organs of nude mice. Cancer Res 46:4109–4115

    Google Scholar 

  40. Onishi T, Machida T, Mori Y, Iizuka N, Masuda F, Mochizuki S, Tsukamoto H, Harada N, (1989) Hyperthermia with simultaneous administration of interferon using established human renal carcinoma heterotransplanted in nude mice. Br J Cancer 63:227–232

    Google Scholar 

  41. Oosterhof GON, Smits GAHJ, Ruyter AE de, Schalken JA, Debruyne FMJ (1990) In vivo effects of high energy shock waves on urological tumors. An evaluation of treatment modalities. J Urol 144:785–789

    Google Scholar 

  42. Oosterhof GON, Smits GAHJ, Ruyter AE de, Schalken JA, Debruyne FMJ (1991) Effects of high energy shock waves combined with biological response modifiers in different human kidney cancer xenografts. Ultrasound Med Biol 17:391–399

    Google Scholar 

  43. Otto U, Huland H, Baisch H, Klöppel G (1984) Transplantation of human renal cell carcinoma into NMRI nu/nu mice: II. Evaluation of response to vinblastine sulfate monotherapy. J Urol 131:134–138

    Google Scholar 

  44. Rangel MC, Pontes JE (1989) Animal models of renal cell carcinoma. Semin Urol 7:237–246

    Google Scholar 

  45. Sass B, Rabstein LS, Madison R, Nims RM, Peters RL, Kelloff GJ (1975) Incidence of spontaneous neoplasms in F 344 rat throughout the natural life-span. J Natl Cancer Inst 54:1449–1456

    Google Scholar 

  46. Sayers TJ, Wiltrout TA, McCormick K, Husted C, Wiltrout RH (1990) Antitumor effects of alpha-interferon and gamma-interferon on a murine renal cancer (Renca) in vitro and in vivo. Cancer Res 50:5414–5420

    Google Scholar 

  47. Schalken JA, Ebeling SB, Isaacs JT, Treiger B, Bussemakers MJG, Jong MEM de, Ven WJM van de (1988) Differential hybridization reveals down-modulation of fibronectin mRNA in metastasizing prostatic cancer cells. Cancer Res 48:2042–2046

    Google Scholar 

  48. Shimizu M, Yokota J, Mori N, Shuin T, Shinoda M, Terada M, Oshimura M (1990) Introduction of normal chromosome 3p modulates the tumorigenicity of a human renal cell carcinoma cell line YCR. Oncogene 5:185–194

    Google Scholar 

  49. Sufrin G (1980) Spontaneous, hormonal, and chemically induced animal models of renal adenocarcinoma. In: Sufrin G, Beckley SA (eds) Renal adenocarcinoma. (Technical report series, vol 49). UICC, Geneva, pp 2–27

    Google Scholar 

  50. Thompson SW, Huseby RA, Fox MA, Davis CL, Hunt RD (1961) Spontaneous tumors in the Sprague-Dawley rat. J Natl Cancer Inst 27:1037–1057

    Google Scholar 

  51. Vandendris M, Dumont P, Heimann R, Atassi G (1983) Development and characterization of a new murine renal tumor model. Chemotherapeutic results. Cancer Chemother Pharmacol 11:182–187

    Google Scholar 

  52. Vere White R de, Olsson RA (1980) Renal adenocarcinoma in the rat. A new tumor model. Invest Urol 17:405–412

    Google Scholar 

  53. Weekes UY (1975) Metabolism of dimethylnitrosamine to mutagenic intermediates by kidney microsomal enzymes and correlation with reported host susceptibility to kidney tumors. J Natl Cancer Inst 55:1199–1201

    Google Scholar 

  54. Weissglas MG, Romijn JC, Dongen JW van, Cappendijk MJ, Ten Kate FJ, Kurth KH (1989) Human renal cell carcinoma in the six day subrenal capsule assay. J Urol 142:1106–1109

    Google Scholar 

  55. Winograd B, Boven E, Lobbezoo MW, Pinedo (1987) Human tumor xenografts in the nude mouse and their value as test models in aniticancer drug development (review). In Vivo 1:1–14

    Google Scholar 

  56. Yamaoka T, Takada H, Yanagi Y, Kataoka T, Sakurai Y (1985) The antitumor effects of human lymphoblastoid interferon on human renal cell carcinoma in athymic nude mice. Cancer Chemother Pharmacol 14:184–187

    Google Scholar 

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Authors and Affiliations

  1. Urologic Research Laboratory, Department of Urology, University Hospital Nijmegen, P.O. Box 9101, NL-6500 HB, Nijmegen, The Netherlands

    R. J. A. van Moorselaar, J. A. Schalken, G. O. N. Oosterhof & F. M. J. Debruyne

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  1. R. J. A. van Moorselaar
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  2. J. A. Schalken
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  3. G. O. N. Oosterhof
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  4. F. M. J. Debruyne
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van Moorselaar, R.J.A., Schalken, J.A., Oosterhof, G.O.N. et al. Use of animal models in diagnosis and treatment of renal cell carcinoma. World J Urol 9, 192–197 (1991). https://doi.org/10.1007/BF00182839

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