Abstract
Stress is an adaptive response to environment aversive stimuli and a common life experience of one’s daily life. Chronic or excessive stress especially that happened in early life is found to be deleterious to individual’s physical and mental health, which is highly related to depressive disorders onset. Stressful life events are consistently considered to be the high-risk factors of environment for predisposing depressive disorders. In linking stressful life events with depressive disorder onset, dysregulated HPA axis activity is supposed to play an important role in mediating aversive impacts of life stress on brain structure and function. Increasing evidence have indicated the strong association of stress, especially the chronic stress and early life stress, with depressive disorders development, while the association of stress with depression is moderated by genetic risk factors, including polymorphism of SERT, BDNF, GR, FKBP5, MR, and CRHR1. Meanwhile, stressful life experience particularly early life stress will exert epigenetic modification in these risk genes via DNA methylation and miRNA regulation to generate long-lasting effects on these genes expression, which in turn cause brain structural and functional alteration, and finally increase the vulnerability to depressive disorders. Therefore, the interaction of environment with gene, in which stressful life exposure interplay with genetic risk factors and epigenetic modification, is essential in predicting depressive disorders development. As the mediator of environmental risk factors, stress will function together with genetic and epigenetic mechanism to influence brain structure and function, physiology and psychology, and finally the vulnerability to depressive disorders.
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References
Abdolmaleky HM, Nohesara S, Ghadirivasfi M, Lambert AW, Ahmadkhaniha H, Ozturk S, Wong CK, Shafa R, Mostafavi A, Thiagalingam S (2014) DNA hypermethylation of serotonin transporter gene promoter in drug naive patients with schizophrenia. Schizophr Res 152:373–380
Abravanel BT, Sinha R (2015) Emotion dysregulation mediates the relationship between lifetime cumulative adversity and depressive symptomatology. J Psychiatr Res 61:89–96
Agorastos A, Pittman, JO, Angkaw AC, Nievergelt CM, Hansen CJ, Aversa LH, Parisi SA, Barkauskas DA, Marine Resiliency Study T, Baker DG (2014) The cumulative effect of different childhood trauma types on self-reported symptoms of adult male depression and PTSD, substance abuse and health-related quality of life in a large active-duty military cohort. J Psychiatr Res 58:46–54
Aguilera M, Arias B, Wichers M, Barrantes-Vidal N, Moya J, Villa H, van Os J, Ibanez MI, Ruiperez MA, Ortet G et al (2009) Early adversity and 5-HTT/BDNF genes: new evidence of gene-environment interactions on depressive symptoms in a general population. Psychol Med 39:1425–1432
Aich P, Potter AA, Griebel PJ (2009) Modern approaches to understanding stress and disease susceptibility: a review with special emphasis on respiratory disease. Int J Gen Med 2:19–32
Alexander N, Osinsky R, Schmitz A, Mueller E, Kuepper Y, Hennig J (2010) The BDNF Val66Met polymorphism affects HPA-axis reactivity to acute stress. Psychoneuroendocrinology 35:949–953
Andersen SL, Teicher MH (2008) Stress, sensitive periods and maturational events in adolescent depression. Trends Neurosci 31:183–191
Appel K, Schwahn C, Mahler J, Schulz A, Spitzer C, Fenske K, Stender J, Barnow S, John U, Teumer A et al (2011) Moderation of adult depression by a polymorphism in the FKBP5 gene and childhood physical abuse in the general population. Neuropsychopharmacology 36:1982–1991
Assari S, Lankarani MM (2016) Stressful life events and risk of depression 25 years later: race and gender differences. Front Public Health 4:49
Avison WR, Turner RJ (1988) Stressful life events and depressive symptoms: disaggregating the effects of acute stressors and chronic strains. J Health Soc Behav 29:253–264
Babenko O, Kovalchuk I, Metz GA (2015) Stress-induced perinatal and transgenerational epigenetic programming of brain development and mental health. Neurosci Biobehav Rev 48:70–91
Babenko O, Golubov A, Ilnytskyy Y, Kovalchuk I, Metz GA (2012) Genomic and epigenomic responses to chronic stress involve miRNA-mediated programming. PLoS ONE 7:e29441
Bagot RC, Labonte B, Pena CJ, Nestler EJ (2014) Epigenetic signaling in psychiatric disorders: stress and depression. Dialogues Clin Neurosci 16:281–295
Bahi A, Chandrasekar V, Dreyer JL (2014) Selective lentiviral-mediated suppression of microRNA124a in the hippocampus evokes antidepressants-like effects in rats. Psychoneuroendocrinology 46:78–87
Bai M, Zhu X, Zhang Y, Zhang S, Zhang L, Xue L, Yi J, Yao S, Zhang X (2012) Abnormal hippocampal BDNF and miR-16 expression is associated with depression-like behaviors induced by stress during early life. PLoS ONE 7:e46921
Bakusic J, Schaufeli W, Claes S, Godderis L (2017) Stress, burnout and depression: a systematic review on DNA methylation mechanisms. J Psychosom Res 92:34–44
Barker ED, Jaffee SR, Uher R, Maughan B (2011) The contribution of prenatal and postnatal maternal anxiety and depression to child maladjustment. Depress Anxiety 28:696–702
Barry TJ, Murray L, Fearon RM, Moutsiana C, Cooper P, Goodyer IM, Herbert J, Halligan SL (2015) Maternal postnatal depression predicts altered offspring biological stress reactivity in adulthood. Psychoneuroendocrinology 52:251–260
Baudry A, Mouillet-Richard S, Schneider B, Launay JM, Kellermann O (2010) miR-16 targets the serotonin transporter: a new facet for adaptive responses to antidepressants. Science 329:1537–1541
Becker JB (2010). Stress and reward. In: Koob GF, Moal ML, Thompson RF (eds) Encyclopedia of behavioral neuroscience. Academic Press, pp 328–333
Begni V, Riva MA, Cattaneo A (2017) Cellular and molecular mechanisms of the brain-derived neurotrophic factor in physiological and pathological conditions. Clin Sci (Lond) 131:123–138
Belda X, Fuentes S, Daviu N, Nadal R, Armario A (2015) Stress-induced sensitization: the hypothalamic-pituitary-adrenal axis and beyond. Stress 18:269–279
Bennett HA, Einarson A, Taddio A, Koren G, Einarson TR (2004) Prevalence of depression during pregnancy: systematic review. Obstet Gynecol 103:698–709
Benson PR (2018) The impact of child and family stressors on the self-rated health of mothers of children with autism spectrum disorder: associations with depressed mood over a 12-year period. Autism 22:489–501
Bet PM, Penninx BW, Bochdanovits Z, Uitterlinden AG, Beekman AT, van Schoor NM, Deeg DJ, Hoogendijk WJ (2009) Glucocorticoid receptor gene polymorphisms and childhood adversity are associated with depression: New evidence for a gene-environment interaction. Am J Med Genet B Neuropsychiatr Genet 150B:660–669
Beydoun H, Saftlas AF (2008) Physical and mental health outcomes of prenatal maternal stress in human and animal studies: a review of recent evidence. Paediatr Perinat Epidemiol 22:438–466
Binder EB (2009) The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders. Psychoneuroendocrinology 34(Suppl 1):S186–S195
Bleys D, Luyten P, Soenens B, Claes S (2018) Gene-environment interactions between stress and 5-HTTLPR in depression: a meta-analytic update. J Affect Disord 226:339–345
Blugeot A, Rivat C, Bouvier E, Molet J, Mouchard A, Zeau B, Bernard C, Benoliel JJ, Becker C (2011) Vulnerability to depression: from brain neuroplasticity to identification of biomarkers. J Neurosci 31:12889–12899
Bockmuhl Y, Patchev AV, Madejska A, Hoffmann A, Sousa JC, Sousa N, Holsboer F, Almeida OF, Spengler D (2015) Methylation at the CpG island shore region upregulates Nr3c1 promoter activity after early-life stress. Epigenetics 10:247–257
Bonfiglio JJ, Inda C, Refojo D, Holsboer F, Arzt E, Silberstein S (2011) The corticotropin-releasing hormone network and the hypothalamic-pituitary-adrenal axis: molecular and cellular mechanisms involved. Neuroendocrinology 94:12–20
Braithwaite EC, Murphy SE, Ramchandani PG (2014) Prenatal risk factors for depression: a critical review of the evidence and potential mechanisms. J Dev Orig Health Dis 5:339–350
Braithwaite EC, Kundakovic M, Ramchandani PG, Murphy SE, Champagne FA (2015) Maternal prenatal depressive symptoms predict infant NR3C1 1F and BDNF IV DNA methylation. Epigenetics 10:408–417
Brennan PA, Pargas R, Walker EF, Green P, Newport DJ, Stowe Z (2008) Maternal depression and infant cortisol: influences of timing, comorbidity and treatment. J Child Psychol Psychiatry 49:1099–1107
Brunoni AR, Lopes M, Fregni F (2008) A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression. Int J Neuropsychopharmacol 11:1169–1180
Bus BA, Molendijk ML (2016) The neurotrophic hypothesis of depression. Tijdschr Psychiatr 58:215–222
Carthew RW, Sontheimer EJ (2009) Origins and mechanisms of miRNAs and siRNAs. Cell 136:642–655
Caspi A, Hariri AR, Holmes A, Uher R, Moffitt TE (2010) Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. Am J Psychiatry 167:509–527
Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, McClay J, Mill J, Martin J, Braithwaite A et al (2003) Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301:386–389
Chaouloff F (2013) Social stress models in depression research: what do they tell us? Cell Tissue Res 354:179–190
Chapman DP, Whitfield CL, Felitti VJ, Dube SR, Edwards VJ, Anda RF (2004) Adverse childhood experiences and the risk of depressive disorders in adulthood. J Affect Disord 82:217–225
Chen Y, Baram TZ (2016) Toward understanding how early-life stress reprograms cognitive and emotional brain networks. Neuropsychopharmacology 41:197–206
Chen ZY, Jing D, Bath KG, Ieraci A, Khan T, Siao CJ, Herrera DG, Toth M, Yang C, McEwen BS et al (2006) Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science 314:140–143
Chipman P, Jorm AF, Prior M, Sanson A, Smart D, Tan X, Easteal S (2007) No interaction between the serotonin transporter polymorphism (5-HTTLPR) and childhood adversity or recent stressful life events on symptoms of depression: results from two community surveys. Am J Med Genet B Neuropsychiatr Genet 144B:561–565
Chirita AL, Gheorman V, Bondari D, Rogoveanu I (2015) Current understanding of the neurobiology of major depressive disorder. Rom J Morphol Embryol 56:651–658
Claes S (2009) Glucocorticoid receptor polymorphisms in major depression. Ann NY Acad Sci 1179:216–228
Clarke H, Flint J, Attwood AS, Munafo MR (2010) Association of the 5-HTTLPR genotype and unipolar depression: a meta-analysis. Psychol Med 40:1767–1778
Cohen S, Janicki-Deverts D, Miller GE (2007) Psychological stress and disease. JAMA 298:1685–1687
Colman I, Ataullahjan A (2010) Life course perspectives on the epidemiology of depression. Can J Psychiatry 55:622–632
Comasco E, Aslund C, Oreland L, Nilsson KW (2013) Three-way interaction effect of 5-HTTLPR, BDNF Val66Met, and childhood adversity on depression: a replication study. Eur Neuropsychopharmacol 23:1300–1306
Conti M, Spulber S, Raciti M, Ceccatelli S (2017) Depressive-like phenotype induced by prenatal dexamethasone in mice is reversed by desipramine. Neuropharmacology 126:242–249
Dalton ED, Hammen CL, Najman JM, Brennan PA (2014) Genetic susceptibility to family environment: BDNF Val66met and 5-HTTLPR influence depressive symptoms. J Fam Psychol 28:947–956
de Kloet ER, Otte C, Kumsta R, Kok L, Hillegers MH, Hasselmann H, Kliegel D, Joels M (2016) Stress and depression: a crucial role of the mineralocorticoid receptor. J Neuroendocrinol 28
Derijk RH, de Kloet ER (2008) Corticosteroid receptor polymorphisms: determinants of vulnerability and resilience. Eur J Pharmacol 583:303–311
Deussing JM, Jakovcevski M (2017) Histone modifications in major depressive disorder and related rodent models. Adv Exp Med Biol 978:169–183
Dirven BCJ, Homberg JR, Kozicz T, Henckens M (2017) Epigenetic programming of the neuroendocrine stress response by adult life stress. J Mol Endocrinol 59:R11–R31
Dunn EC, Brown RC, Dai Y, Rosand J, Nugent NR, Amstadter AB, Smoller JW (2015) Genetic determinants of depression: recent findings and future directions. Harv Rev Psychiatry 23:1–18
Farrell C, Doolin K, O’ Leary N, Jairaj C, Roddy D, Tozzi L, Morris D, Harkin A, Frodl T, Nemoda Z et al (2018) DNA methylation differences at the glucocorticoid receptor gene in depression are related to functional alterations in hypothalamic-pituitary-adrenal axis activity and to early life emotional abuse. Psychiatry Res 265:341–348
Eckenrode J (1984) Impact of chronic and acute stressors on daily reports of mood. J Pers Soc Psychol 46:907–918
Efstathopoulos P, Andersson F, Melas PA, Yang LL, Villaescusa JC, Ruegg J, Ekstrom TJ, Forsell Y, Galanti MR, Lavebratt C (2018) NR3C1 hypermethylation in depressed and bullied adolescents. Transl Psychiatry 8:121
Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, Zaitsev E, Gold B, Goldman D, Dean M et al (2003) The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112:257–269
Eisenmann ED, Rorabaugh BR, Zoladz PR (2016) Acute stress decreases but chronic stress increases myocardial sensitivity to ischemic injury in rodents. Front Psychiatry 7:71
Essex MJ, Klein MH, Cho E, Kalin NH (2002) Maternal stress beginning in infancy may sensitize children to later stress exposure: effects on cortisol and behavior. Biol Psychiatry 52:776–784
Fatima M, Srivastav S, Mondal AC (2017) Prenatal stress and depression associated neuronal development in neonates. Int J Dev Neurosci 60:1–7
Fellmeth G, Fazel M, Plugge E (2017) Migration and perinatal mental health in women from low- and middle-income countries: a systematic review and meta-analysis. BJOG 124:742–752
Flint J, Kendler KS (2014) The genetics of major depression. Neuron 81:1214
Fuchikami M, Morinobu S, Segawa M, Okamoto Y, Yamawaki S, Ozaki N, Inoue T, Kusumi I, Koyama T, Tsuchiyama K et al (2011) DNA methylation profiles of the brain-derived neurotrophic factor (BDNF) gene as a potent diagnostic biomarker in major depression. PLoS ONE 6:e23881
Fuhrmann D, Knoll LJ, Blakemore SJ (2015) Adolescence as a sensitive period of brain development. Trends Cogn Sci 19:558–566
Gao J, Pan Z, Jiao Z, Li F, Zhao G, Wei Q, Pan F, Evangelou E (2012) TPH2 gene polymorphisms and major depression—a meta-analysis. PLoS ONE 7:e36721
Gatt JM, Burton KL, Williams LM, Schofield PR (2015) Specific and common genes implicated across major mental disorders: a review of meta-analysis studies. J Psychiatr Res 60:1–13
Gatt JM, Nemeroff CB, Dobson-Stone C, Paul RH, Bryant RA, Schofield PR, Gordon E, Kemp AH, Williams LM (2009) Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety. Mol Psychiatry 14:681–695
Gelaye B, Rondon MB, Araya R, Williams MA (2016) Epidemiology of maternal depression, risk factors, and child outcomes in low-income and middle-income countries. Lancet Psychiatry 3:973–982
Gilpin NW (2014) Brain reward and stress systems in addiction. Front Psychiatry 5:79
Glover V (2014) Maternal depression, anxiety and stress during pregnancy and child outcome; what needs to be done. Best Pract Res Clin Obstet Gynaecol 28:25–35
Golbidi S, Frisbee JC, Laher I (2015) Chronic stress impacts the cardiovascular system: animal models and clinical outcomes. Am J Physiol Heart Circ Physiol 308:H1476–H1498
Grabe HJ, Schwahn C, Appel K, Mahler J, Schulz A, Spitzer C, Fenske K, Barnow S, Lucht M, Freyberger HJ et al (2010) Childhood maltreatment, the corticotropin-releasing hormone receptor gene and adult depression in the general population. Am J Med Genet B Neuropsychiatr Genet 153B:1483–1493
Grimm S, Wirth K, Fan Y, Weigand A, Gartner M, Feeser M, Dziobek I, Bajbouj M, Aust S (2017) The interaction of corticotropin-releasing hormone receptor gene and early life stress on emotional empathy. Behav Brain Res 329:180–185
Groves JO (2007) Is it time to reassess the BDNF hypothesis of depression? Mol Psychiatry 12:1079–1088
Guidotti G, Calabrese F, Anacker C, Racagni G, Pariante CM, Riva MA (2013) Glucocorticoid receptor and FKBP5 expression is altered following exposure to chronic stress: modulation by antidepressant treatment. Neuropsychopharmacology 38:616–627
Halligan SL, Herbert J, Goodyer IM, Murray L (2004) Exposure to postnatal depression predicts elevated cortisol in adolescent offspring. Biol Psychiatry 55:376–381
Halligan SL, Herbert J, Goodyer I, Murray L (2007a) Disturbances in morning cortisol secretion in association with maternal postnatal depression predict subsequent depressive symptomatology in adolescents. Biol Psychiatry 62:40–46
Halligan SL, Murray L, Martins C, Cooper PJ (2007b) Maternal depression and psychiatric outcomes in adolescent offspring: a 13-year longitudinal study. J Affect Disord 97:145–154
Hammen C (2005) Stress and depression. Annu Rev Clin Psychol 1:293–319
Hammen C, Brennan PA (2003) Severity, chronicity, and timing of maternal depression and risk for adolescent offspring diagnoses in a community sample. Arch Gen Psychiatry 60:253–258
Han KM, Won E, Sim Y, Kang J, Han C, Kim YK, Kim SH, Joe SH, Lee MS, Tae WS et al (2017) Influence of FKBP5 polymorphism and DNA methylation on structural changes of the brain in major depressive disorder. Sci Rep 7:42621
Haramati S, Navon I, Issler O, Ezra-Nevo G, Gil S, Zwang R, Hornstein E, Chen A (2011) MicroRNA as repressors of stress-induced anxiety: the case of amygdalar miR-34. J Neurosci 31:14191–14203
Hardeveld F, Spijker J, Peyrot WJ, de Graaf R, Hendriks SM, Nolen WA, Penninx BW, Beekman AT (2015) Glucocorticoid and mineralocorticoid receptor polymorphisms and recurrence of major depressive disorder. Psychoneuroendocrinology 55:154–163
He SC, Wu S, Wang C, Du XD, Yin G, Jia Q, Zhang Y, Wang L, Soares JC, Zhang XY (2018) Interaction between job stress and the BDNF Val66Met polymorphism affects depressive symptoms in Chinese healthcare workers. J Affect Disord 236:157–163
Heils A, Teufel A, Petri S, Stober G, Riederer P, Bengel D, Lesch KP (1996) Allelic variation of human serotonin transporter gene expression. J Neurochem 66:2621–2624
Heim C, Binder EB (2012) Current research trends in early life stress and depression: review of human studies on sensitive periods, gene-environment interactions, and epigenetics. Exp Neurol 233:102–111
Heim C, Shugart M, Craighead WE, Nemeroff CB (2010) Neurobiological and psychiatric consequences of child abuse and neglect. Dev Psychobiol 52:671–690
Higuchi F, Uchida S, Yamagata H, Abe-Higuchi N, Hobara T, Hara K, Kobayashi A, Shintaku T, Itoh Y, Suzuki T et al (2016) Hippocampal MicroRNA-124 enhances chronic stress resilience in mice. J Neurosci 36:7253–7267
Hollis F, Kabbaj M (2014) Social defeat as an animal model for depression. ILAR J 55:221–232
Homberg JR, Molteni R, Calabrese F, Riva MA (2014) The serotonin-BDNF duo: developmental implications for the vulnerability to psychopathology. Neurosci Biobehav Rev 43:35–47
Horowitz MA, Zunszain PA (2015) Neuroimmune and neuroendocrine abnormalities in depression: two sides of the same coin. Ann NY Acad Sci 1351:68–79
Hosang GM, Shiles C, Tansey KE, McGuffin P, Uher R (2014) Interaction between stress and the BDNF Val66Met polymorphism in depression: a systematic review and meta-analysis. BMC Med 12:7
Hranilovic D, Stefulj J, Schwab S, Borrmann-Hassenbach M, Albus M, Jernej B, Wildenauer D (2004) Serotonin transporter promoter and intron 2 polymorphisms: relationship between allelic variants and gene expression. Biol Psychiatry 55:1090–1094
Infurna MR, Reichl C, Parzer P, Schimmenti A, Bifulco A, Kaess M (2016) Associations between depression and specific childhood experiences of abuse and neglect: a meta-analysis. J Affect Disord 190:47–55
Ismaylova E, Levesque ML, Pomares FB, Szyf M, Nemoda Z, Fahim C, Vitaro F, Brendgen M, Dionne G, Boivin M et al (2018) Serotonin transporter promoter methylation in peripheral cells and neural responses to negative stimuli: a study of adolescent monozygotic twins. Transl Psychiatry 8:147
Januar V, Saffery R, Ryan J (2015) Epigenetics and depressive disorders: a review of current progress and future directions. Int J Epidemiol 44:1364–1387
Jeon SW, Kim YK (2018) Application of assessment tools to examine mental health in workplaces: job stress and depression. Psychiatry Investig 15:553–560
Jiang R, Brummett BH, Babyak MA, Siegler IC, Williams RB (2013) Brain-derived neurotrophic factor (BDNF) Val66Met and adulthood chronic stress interact to affect depressive symptoms. J Psychiatr Res 47:233–239
Jiang X, Xu K, Hoberman J, Tian F, Marko AJ, Waheed JF, Harris CR, Marini AM, Enoch MA, Lipsky RH (2005) BDNF variation and mood disorders: a novel functional promoter polymorphism and Val66Met are associated with anxiety but have opposing effects. Neuropsychopharmacology 30:1353–1361
Juruena MF, Cleare AJ, Pariante CM (2004) The hypothalamic pituitary adrenal axis, glucocorticoid receptor function and relevance to depression. Rev Bras Psiquiatr 26:189–201
Juruena MF, Werne Baes CV, Menezes IC, Graeff FG (2015) Early life stress in depressive patients: role of glucocorticoid and mineralocorticoid receptors and of hypothalamic-pituitary-adrenal axis activity. Curr Pharm Des 21:1369–1378
Kang HJ, Kim JM, Stewart R, Kim SY, Bae KY, Kim SW, Shin IS, Shin MG, Yoon JS (2013) Association of SLC6A4 methylation with early adversity, characteristics and outcomes in depression. Prog Neuropsychopharmacol Biol Psychiatry 44:23–28
Karg K, Burmeister M, Shedden K, Sen S (2011) The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation. Arch Gen Psychiatry 68:444–454
Keller S, Sarchiapone M, Zarrilli F, Videtic A, Ferraro A, Carli V, Sacchetti S, Lembo F, Angiolillo A, Jovanovic N et al (2010) Increased BDNF promoter methylation in the Wernicke area of suicide subjects. Arch Gen Psychiatry 67:258–267
Kendler KS, Karkowski LM, Prescott CA (1998) Stressful life events and major depression: risk period, long-term contextual threat, and diagnostic specificity. J Nerv Ment Dis 186:661–669
Kendler KS, Karkowski LM, Prescott CA (1999) Causal relationship between stressful life events and the onset of major depression. Am J Psychiatry 156:837–841
Kendler KS, Kuhn J, Prescott CA (2004) The interrelationship of neuroticism, sex, and stressful life events in the prediction of episodes of major depression. Am J Psychiatry 161:631–636
Kessing LV, Bukh JD (2013) Genetics and stressful life events interact in depression. Ugeskr Laeger 175:948–951
Kessler RC, Bromet EJ (2013) The epidemiology of depression across cultures. Annu Rev Public Health 34:119–138
Kishi T, Yoshimura R, Fukuo Y, Okochi T, Matsunaga S, Umene-Nakano W, Nakamura J, Serretti A, Correll CU, Kane JM et al (2013) The serotonin 1A receptor gene confer susceptibility to mood disorders: results from an extended meta-analysis of patients with major depression and bipolar disorder. Eur Arch Psychiatry Clin Neurosci 263:105–118
Kivimaki M, Steptoe A (2018) Effects of stress on the development and progression of cardiovascular disease. Nat Rev Cardiol 15:215–229
Klengel T, Binder EB (2013) Gene-environment interactions in major depressive disorder. Can J Psychiatry 58:76–83
Klengel T, Pape J, Binder EB, Mehta D (2014) The role of DNA methylation in stress-related psychiatric disorders. Neuropharmacology 80:115–132
Klengel T, Mehta D, Anacker C, Rex-Haffner M, Pruessner JC, Pariante CM, Pace TW, Mercer KB, Mayberg HS, Bradley B et al (2013) Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions. Nat Neurosci 16:33–41
Kohrt BA, Worthman CM, Ressler KJ, Mercer KB, Upadhaya N, Koirala S, Nepal MK, Sharma VD, Binder EB (2015) Cross-cultural gene- environment interactions in depression, post-traumatic stress disorder, and the cortisol awakening response: FKBP5 polymorphisms and childhood trauma in South Asia. Int Rev Psychiatry 27:180–196
Kranzler HR, Feinn R, Nelson EC, Covault J, Anton RF, Farrer L, Gelernter J (2011) A CRHR1 haplotype moderates the effect of adverse childhood experiences on lifetime risk of major depressive episode in African–American women. Am J Med Genet B Neuropsychiatr Genet 156B:960–968
Kumsta R, Entringer S, Koper JW, van Rossum EF, Hellhammer DH, Wust S (2007) Sex specific associations between common glucocorticoid receptor gene variants and hypothalamus-pituitary-adrenal axis responses to psychosocial stress. Biol Psychiatry 62:863–869
Laceulle OM, O’Donnell K, Glover V, O’Connor TG, Ormel J, van Aken MAG, Nederhof E (2014) Stressful events and psychological difficulties: testing alternative candidates for sensitivity. Eur Child Adoles Psy 23:103–113
La Greca AM, Lai BS, Joormann J, Auslander BB, Short MA (2013) Children’s risk and resilience following a natural disaster: genetic vulnerability, posttraumatic stress, and depression. J Affect Disord 151:860–867
Lamb YN, McKay NS, Thompson CS, Hamm JP, Waldie KE, Kirk IJ (2015) Brain-derived neurotrophic factor Val66Met polymorphism, human memory, and synaptic neuroplasticity. Wiley Interdiscip Rev Cogn Sci 6:97–108
Larrieu T, Sandi C (2018) Stress-induced depression: is social rank a predictive risk factor? BioEssays 40:e1800012
Laudenslager ML (1987) Psychosocial stress and susceptibility to infectious disease. In: Kurstak E, Lipowski ZJ, Morozov PV (eds) Viruses, immunity, and mental disorders. Springer, US, pp 391–402
Laugharne J, Lillee A, Janca A (2010) Role of psychological trauma in the cause and treatment of anxiety and depressive disorders. Curr Opin Psychiatry 23:25–29
Launay JM, Mouillet-Richard S, Baudry A, Pietri M, Kellermann O (2011) Raphe-mediated signals control the hippocampal response to SRI antidepressants via miR-16. Transl Psychiatry 1:e56
Laursen TM, Musliner KL, Benros ME, Vestergaard M, Munk-Olsen T (2016) Mortality and life expectancy in persons with severe unipolar depression. J Affect Disord 193:203–207
Lavebratt C, Aberg E, Sjoholm LK, Forsell Y (2010) Variations in FKBP5 and BDNF genes are suggestively associated with depression in a Swedish population-based cohort. J Affect Disord 125:249–255
Lee PH, Perlis RH, Jung JY, Byrne EM, Rueckert E, Siburian R, Haddad S, Mayerfeld CE, Heath AC, Pergadia ML et al (2012) Multi-locus genome-wide association analysis supports the role of glutamatergic synaptic transmission in the etiology of major depressive disorder. Transl Psychiatry 2:e184
Li Y, Li S, Yan J, Wang D, Yin R, Zhao L, Zhu Y, Zhu X (2016) miR-182 (microRNA-182) suppression in the hippocampus evokes antidepressant-like effects in rats. Prog Neuropsychopharmacol Biol Psychiatry 65:96–103
Li HY, Jiang QS, Fu XY, Jiang XH, Zhou QX, Qiu HM (2017) Abnormal modification of histone acetylation involved in depression-like behaviors of rats induced by chronically unpredicted stress. NeuroReport 28:1054–1060
Li YJ, Xu M, Gao ZH, Wang YQ, Yue Z, Zhang YX, Li XX, Zhang C, Xie SY, Wang PY (2013) Alterations of serum levels of BDNF-related miRNAs in patients with depression. PLoS ONE 8:e63648
Lin YL, Wang S (2014) Prenatal lipopolysaccharide exposure increases depression-like behaviors and reduces hippocampal neurogenesis in adult rats. Behav Brain Res 259:24–34
Lindert J, von Ehrenstein OS, Grashow R, Gal G, Braehler E, Weisskopf MG (2014) Sexual and physical abuse in childhood is associated with depression and anxiety over the life course: systematic review and meta-analysis. Int J Public Health 59:359–372
Liu Y, Liu D, Xu J, Jiang H, Pan F (2017a) Early adolescent stress-induced changes in prefrontal cortex miRNA-135a and hippocampal miRNA-16 in male rats. Dev Psychobiol 59:958–969
Liu YY, Zhou XY, Yang LN, Wang HY, Zhang YQ, Pu JC, Liu LX, Gui SW, Zeng L, Chen JJ et al (2017b) Social defeat stress causes depression-like behavior with metabolite changes in the prefrontal cortex of rats. PLoS ONE 12:e0176725
Liu D, Qiu HM, Fei HZ, Hu XY, Xia HJ, Wang LJ, Qin LJ, Jiang XH, Zhou QX (2014) Histone acetylation and expression of mono-aminergic transmitters synthetases involved in CUS-induced depressive rats. Exp Biol Med (Maywood) 239:330–336
Lopez-Leon S, Janssens AC, Gonzalez-Zuloeta Ladd AM, Del-Favero J, Claes SJ, Oostra BA, van Duijn CM (2008) Meta-analyses of genetic studies on major depressive disorder. Mol Psychiatry 13:772–785
Lopizzo N, Bocchio Chiavetto L, Cattane N, Plazzotta G, Tarazi FI, Pariante CM, Riva MA, Cattaneo A (2015) Gene-environment interaction in major depression: focus on experience-dependent biological systems. Front Psychiatry 6:68
Lu B, Nagappan G, Lu Y (2014) BDNF and synaptic plasticity, cognitive function, and dysfunction. Handb Exp Pharmacol 220:223–250
Lucassen PJ, Pruessner J, Sousa N, Almeida OF, Van Dam AM, Rajkowska G, Swaab DF, Czeh B (2014) Neuropathology of stress. Acta Neuropathol 127:109–135
Lueboonthavatchai P (2009) Role of stress areas, stress severity, and stressful life events on the onset of depressive disorder: a case-control study. J Med Assoc Thai 92:1240–1249
Luo Y, Cao Z, Wang D, Wu L, Li Y, Sun W, Zhu Y (2014) Dynamic study of the hippocampal volume by structural MRI in a rat model of depression. Neurol Sci 35:1777–1783
Ma K, Guo L, Xu A, Cui S, Wang JH (2016) Molecular mechanism for stress-induced depression assessed by sequencing miRNA and mRNA in medial prefrontal Cortex. PLoS ONE 11:e0159093
Maciejewski PK, Prigerson HG, Mazure CM (2001) Sex differences in event-related risk for major depression. Psychol Med 31:593–604
Maguire J, Mody I (2016) Behavioral deficits in Juveniles mediated by maternal stress hormones in mice. Neural Plast 2016:2762518
Mandelli L, Petrelli C, Serretti A (2015) The role of specific early trauma in adult depression: A meta-analysis of published literature: childhood trauma and adult depression. Eur Psychiatry 30:665–680
Martinowich K, Manji H, Lu B (2007) New insights into BDNF function in depression and anxiety. Nat Neurosci 10:1089–1093
Mazure CM, Bruce ML, Maciejewski PK, Jacobs SC (2000) Adverse life events and cognitive-personality characteristics in the prediction of major depression and antidepressant response. Am J Psychiatry 157:896–903
McGowan PO, Sasaki A, D’Alessio AC, Dymov S, Labonte B, Szyf M, Turecki G, Meaney MJ (2009) Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci 12:342–348
McGuffin P, Katz R, Watkins S, Rutherford J (1996) A hospital-based twin register of the heritability of DSM-IV unipolar depression. Arch Gen Psychiatry 53:129–136
Menke A, Klengel T, Rubel J, Bruckl T, Pfister H, Lucae S, Uhr M, Holsboer F, Binder EB (2013) Genetic variation in FKBP5 associated with the extent of stress hormone dysregulation in major depression. Genes Brain Behav 12:289–296
Molendijk ML, Spinhoven P, Polak M, Bus BA, Penninx BW, Elzinga BM (2014) Serum BDNF concentrations as peripheral manifestations of depression: evidence from a systematic review and meta-analyses on 179 associations (N = 9484). Mol Psychiatry 19:791–800
Monroe SM, Slavich GM, Gotlib IH (2014) Life stress and family history for depression: the moderating role of past depressive episodes. J Psychiatr Res 49:90–95
Monti JD, Rudolph KD (2017) Maternal depression and trajectories of adolescent depression: the role of stress responses in youth risk and resilience. Dev Psychopathol 29:1413–1429
Morse JQ, Robins CJ (2005) Personality–life event congruence effects in late-life depression. J Affect Disord 84:25–31
Mothersill O, Donohoe G (2016) Neural effects of social environmental stress—an activation likelihood estimation meta-analysis. Psychol Med 46:2015–2023
Moya PR, Wendland JR, Salemme J, Fried RL, Murphy DL (2013) miR-15a and miR-16 regulate serotonin transporter expression in human placental and rat brain raphe cells. Int J Neuropsychopharmacol 16:621–629
Mulder RH, Rijlaarsdam J, Luijk MP, Verhulst FC, Felix JF, Tiemeier H, Bakermans-Kranenburg MJ, Van Ijzendoorn MH (2017) Methylation matters: FK506 binding protein 51 (FKBP5) methylation moderates the associations of FKBP5 genotype and resistant attachment with stress regulation. Dev Psychopathol 29:491–503
Mullins N, Power RA, Fisher HL, Hanscombe KB, Euesden J, Iniesta R, Levinson DF, Weissman MM, Potash JB, Shi J et al (2016) Polygenic interactions with environmental adversity in the aetiology of major depressive disorder. Psychol Med 46:759–770
Murray F, Smith DW, Hutson PH (2008) Chronic low dose corticosterone exposure decreased hippocampal cell proliferation, volume and induced anxiety and depression like behaviours in mice. Eur J Pharmacol 583:115–127
Murray L, Halligan SL, Goodyer I, Herbert J (2010) Disturbances in early parenting of depressed mothers and cortisol secretion in offspring: a preliminary study. J Affect Disord 122:218–223
Murray L, Arteche A, Fearon P, Halligan S, Goodyer I, Cooper P (2011) Maternal postnatal depression and the development of depression in offspring up to 16 years of age. J Am Acad Child Adolesc Psychiatry 50:460–470
Musić S, Rossell SL (2016) Stress, memory, and memory impairment. In: Fink G (ed) Stress: concepts, cognition, emotion, and behavior. Academic Press, pp 145–152
Myers B, McKlveen JM, Herman JP (2014) Glucocorticoid actions on synapses, circuits, and behavior: implications for the energetics of stress. Front Neuroendocrinol 35:180–196
Myruski S, Denefrio S, Dennis-Tiwary TA (2018) Stress and emotion regulation: the dynamic fit model. In: Harkness K, Hayden EP (eds) The Oxford handbook of stress and mental health. Oxford University Press
Nemeroff CB (2016) Paradise lost: the neurobiological and clinical consequences of child Abuse and Neglect. Neuron 89:892–909
Nemoda Z, Szyf M (2017) Epigenetic alterations and prenatal maternal depression. Birth Defects Res 109:888–897
Ngoupaye GT, Yassi FB, Bahane DAN, Bum EN (2018) Combined corticosterone treatment and chronic restraint stress lead to depression associated with early cognitive deficits in mice. Metab Brain Dis 33:421–431
Non AL, Hollister BM, Humphreys KL, Childebayeva A, Esteves K, Zeanah CH, Fox NA, Nelson CA, Drury SS (2016) DNA methylation at stress-related genes is associated with exposure to early life institutionalization. Am J Phys Anthropol 161:84–93
Northoff G (2013) Gene, brains, and environment-genetic neuroimaging of depression. Curr Opin Neurobiol 23:133–142
Ohlin B, Nilsson PM, Nilsson JA, Berglund G (2004) Chronic psychosocial stress predicts long-term cardiovascular morbidity and mortality in middle-aged men. Eur Heart J 25:867–873
Oldehinkel AJ, Ormel J, Verhulst FC, Nederhof E (2014) Childhood adversities and adolescent depression: a matter of both risk and resilience. Dev Psychopathol 26:1067–1075
O’Leary JC 3rd, Zhang B, Koren J 3rd, Blair L, Dickey CA (2013) The role of FKBP5 in mood disorders: action of FKBP5 on steroid hormone receptors leads to questions about its evolutionary importance. CNS Neurol Disord: Drug Targets 12:1157–1162
Osborne S, Biaggi A, Chua TE, Du Preez A, Hazelgrove K, Nikkheslat N, Previti G, Zunszain PA, Conroy S, Pariante CM (2018) Antenatal depression programs cortisol stress reactivity in offspring through increased maternal inflammation and cortisol in pregnancy: the psychiatry research and motherhood—depression (PRAM-D) study. Psychoneuroendocrinology
Otte C, Gold SM, Penninx BW, Pariante CM, Etkin A, Fava M, Mohr DC, Schatzberg AF (2016) Major depressive disorder. Nat Rev Dis Primers 2:16065
Owen D, Andrews MH, Matthews SG (2005) Maternal adversity, glucocorticoids and programming of neuroendocrine function and behaviour. Neurosci Biobehav Rev 29:209–226
Palazidou E (2012) The neurobiology of depression. Br Med Bull 101:127–145
Palma-Gudiel H, Fananas L (2017) An integrative review of methylation at the serotonin transporter gene and its dialogue with environmental risk factors, psychopathology and 5-HTTLPR. Neurosci Biobehav Rev 72:190–209
Pariante CM, Lightman SL (2008) The HPA axis in major depression: classical theories and new developments. Trends Neurosci 31:464–468
Park S, Hatim A, Si TM, Jeon HJ, Srisurapanont M, Bautista D, Liu SI, Chua HC, Hong JP (2015) Stressful life events preceding the onset of depression in Asian patients with major depressive disorder. Int J Soc Psychiatry 61:735–742
Pashkow FJ (1999) Is stress linked to heart disease? The evidence grows stronger. Cleve Clin J Med 66:75–77
Paykel ES (2003) Life events and affective disorders. Acta Psychiatr Scand Suppl 61–66
Pearson RM, Evans J, Kounali D, Lewis G, Heron J, Ramchandani PG, O’Connor TG, Stein A (2013) Maternal depression during pregnancy and the postnatal period: risks and possible mechanisms for offspring depression at age 18 years. JAMA Psychiatry 70:1312–1319
Perroud N, Paoloni-Giacobino A, Prada P, Olie E, Salzmann A, Nicastro R, Guillaume S, Mouthon D, Stouder C, Dieben K et al (2011) Increased methylation of glucocorticoid receptor gene (NR3C1) in adults with a history of childhood maltreatment: a link with the severity and type of trauma. Transl Psychiatry 1:e59
Philibert RA, Sandhu H, Hollenbeck N, Gunter T, Adams W, Madan A (2008) The relationship of 5HTT (SLC6A4) methylation and genotype on mRNA expression and liability to major depression and alcohol dependence in subjects from the Iowa Adoption Studies. Am J Med Genet B Neuropsychiatr Genet 147B:543–549
Pinquart M, Sorensen S (2003) Differences between caregivers and noncaregivers in psychological health and physical health: a meta-analysis. Psychol Aging 18:250–267
Pitney WA, Weuve C, Mazerolle SM (2016) Experiences with and perceptions of workplace bullying among athletic trainers in the secondary school setting. J Athl Train 51:709–716
Polanczyk G, Caspi A, Williams B, Price TS, Danese A, Sugden K, Uher R, Poulton R, Moffitt TE (2009) Protective effect of CRHR1 gene variants on the development of adult depression following childhood maltreatment: replication and extension. Arch Gen Psychiatry 66:978–985
Provenzi L, Giorda R, Beri S, Montirosso R (2016) SLC6A4 methylation as an epigenetic marker of life adversity exposures in humans: a systematic review of literature. Neurosci Biobehav Rev 71:7–20
Ragen BJ, Roach AE, Chollak CL (2016) Chronic stress, regulation of emotion, and functional activity of the brain. In: Fink G (ed) Stress: concepts, cognition, emotion, and behavior. Academic Press, pp 241–249
Rakers F, Rupprecht S, Dreiling M, Bergmeier C, Witte OW, Schwab M (2017) Transfer of maternal psychosocial stress to the fetus. Neurosci Biobehav Rev pii: S0149-7634(16)30719-9
Raposa E, Hammen C, Brennan P, Najman J (2014) The long-term effects of maternal depression: early childhood physical health as a pathway to offspring depression. J Adolesc Health 54:88–93
Ressler KJ, Bradley B, Mercer KB, Deveau TC, Smith AK, Gillespie CF, Nemeroff CB, Cubells JF, Binder EB (2010) Polymorphisms in CRHR1 and the serotonin transporter loci: gene x gene x environment interactions on depressive symptoms. Am J Med Genet B Neuropsychiatr Genet 153B:812–824
Richter-Levin G, Xu L (2018) How could stress lead to major depressive disorder? IBRO Reports 4:38–43
Risch N, Herrell R, Lehner T, Liang KY, Eaves L, Hoh J, Griem A, Kovacs M, Ott J, Merikangas KR (2009) Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. JAMA 301:2462–2471
Roca M, Gili M, Garcia-Campayo J, Armengol S, Bauza N, Garcia-Toro M (2013) Stressful life events severity in patients with first and recurrent depressive episodes. Soc Psychiatry Psychiatr Epidemiol 48:1963–1969
Rodriguez JM, Monsalves-Alvarez M, Henriquez S, Llanos MN, Troncoso R (2016) Glucocorticoid resistance in chronic diseases. Steroids 115:182–192
Rogers J, Raveendran M, Fawcett GL, Fox AS, Shelton SE, Oler JA, Cheverud J, Muzny DM, Gibbs RA, Davidson RJ et al (2013) CRHR1 genotypes, neural circuits and the diathesis for anxiety and depression. Mol Psychiatry 18:700–707
Roth TL, Lubin FD, Funk AJ, Sweatt JD (2009) Lasting epigenetic influence of early-life adversity on the BDNF gene. Biol Psychiatry 65:760–769
Roy B, Dunbar M, Shelton RC, Dwivedi Y (2017a) Identification of MicroRNA-124-3p as a putative epigenetic signature of major depressive disorder. Neuropsychopharmacology 42:864–875
Roy B, Shelton RC, Dwivedi Y (2017b) DNA methylation and expression of stress related genes in PBMC of MDD patients with and without serious suicidal ideation. J Psychiatr Res 89:115–124
Rutters F, Pilz S, Koopman AD, Rauh SP, Te Velde SJ, Stehouwer CD, Elders PJ, Nijpels G, Dekker JM (2014) The association between psychosocial stress and mortality is mediated by lifestyle and chronic diseases: the Hoorn Study. Soc Sci Med 118:166–172
Sanger C, Iles JE, Andrew CS, Ramchandani PG (2015) Associations between postnatal maternal depression and psychological outcomes in adolescent offspring: a systematic review. Arch Womens Ment Health 18:147–162
Saul A, Taylor B, Simpson S Jr, Ponsonby AL, Blizzard L, Dwyer T, McMorran B, Wood B, van der Mei IA (2018) Polymorphism in the serotonin transporter gene polymorphisms (5-HTTLPR) modifies the association between significant life events and depression in people with multiple sclerosis. Mult Scler 25(6):848–855
Schneiderman N, Ironson G, Siegel SD (2005) Stress and health: psychological, behavioral, and biological determinants. Annu Rev Clin Psychol 1:607–628
Schulz PE, Arora G (2015) Depression. Continuum (Minneap Minn) 21:756–771
Seo MK, Ly NN, Lee CH, Cho HY, Choi CM, Nhu LH, Lee JG, Lee BJ, Kim GM, Yoon BJ et al (2016) Early life stress increases stress vulnerability through BDNF gene epigenetic changes in the rat hippocampus. Neuropharmacology 105:388–397
Shadrina M, Bondarenko EA, Slominsky PA (2018) Genetics factors in major depression disease. Front Psychiatry 9:334
Shalev I, Lerer E, Israel S, Uzefovsky F, Gritsenko I, Mankuta D, Ebstein RP, Kaitz M (2009) BDNF Val66Met polymorphism is associated with HPA axis reactivity to psychological stress characterized by genotype and gender interactions. Psychoneuroendocrinology 34:382–388
Shao QY, You F, Zhang YH, Hu LL, Liu WJ, Liu Y, Li J, Wang SD, Song MF (2018) CSF miR-16 expression and its association with miR-16 and serotonin transporter in the raphe of a rat model of depression. J Affect Disord 238:609–614
Sharpley CF, Palanisamy SK, Glyde NS, Dillingham PW, Agnew LL (2014) An update on the interaction between the serotonin transporter promoter variant (5-HTTLPR), stress and depression, plus an exploration of non-confirming findings. Behav Brain Res 273:89–105
Sheline YI, Wang PW, Gado MH, Csernansky JG, Vannier MW (1996) Hippocampal atrophy in recurrent major depression. Proc Natl Acad Sci USA 93:3908–3913
Sickmann HM, Arentzen TS, Dyrby TB, Plath N, Kristensen MP (2015) Prenatal stress produces sex-specific changes in depression-like behavior in rats: implications for increased vulnerability in females. J Dev Orig Health Dis 6:462–474
Sinha R (2012) How Does stress lead to risk of alcohol relapse? Alcohol Res-Curr Rev 34:432–440
Slykerman RF, Thompson J, Waldie K, Murphy R, Wall C, Mitchell EA (2015) Maternal stress during pregnancy is associated with moderate to severe depression in 11-year-old children. Acta Paediatr 104:68–74
Smart C, Strathdee G, Watson S, Murgatroyd C, McAllister-Williams RH (2015) Early life trauma, depression and the glucocorticoid receptor gene–an epigenetic perspective. Psychol Med 45:3393–3410
Smoller JW (2016) The genetics of stress-related disorders: PTSD, depression, and anxiety disorders. Neuropsychopharmacology 41:297–319
Song MF, Dong JZ, Wang YW, He J, Ju X, Zhang L, Zhang YH, Shi JF, Lv YY (2015) CSF miR-16 is decreased in major depression patients and its neutralization in rats induces depression-like behaviors via a serotonin transmitter system. J Affect Disord 178:25–31
Sotelo JL, Musselman D, Nemeroff C (2014) The biology of depression in cancer and the relationship between depression and cancer progression. Int Rev Psychiatry 26:16–30
Spanagel R, Noori HR, Heilig M (2014) Stress and alcohol interactions: animal studies and clinical significance. Trends Neurosci 37:219–227
Sperner-Unterweger B (2015) Depression in cancer patients. Wien Med Wochenschr 165:297–303
Stein DJ, Daniels WM, Savitz J, Harvey BH (2008) Brain-derived neurotrophic factor: the neurotrophin hypothesis of psychopathology. CNS Spectr 13:945–949
Steine IM, Winje D, Krystal JH, Bjorvatn B, Milde AM, Gronli J, Nordhus IH, Pallesen S (2017) Cumulative childhood maltreatment and its dose-response relation with adult symptomatology: Findings in a sample of adult survivors of sexual abuse. Child Abuse Negl 65:99–111
Steptoe A, Kivimaki M (2012) Stress and cardiovascular disease. Nat Rev Cardiol 9:360–370
Su M, Hong J, Zhao Y, Liu S, Xue X (2015) MeCP2 controls hippocampal brain-derived neurotrophic factor expression via homeostatic interactions with microRNA132 in rats with depression. Mol Med Rep 12:5399–5406
Suderman M, Borghol N, Pappas JJ, Pinto Pereira SM, Pembrey M, Hertzman C, Power C, Szyf M (2014) Childhood abuse is associated with methylation of multiple loci in adult DNA. BMC Med Genomics 7:13
Sullivan PF, Neale MC, Kendler KS (2000) Genetic epidemiology of major depression: review and meta-analysis. Am J Psychiatry 157:1552–1562
Sun H, Kennedy PJ, Nestler EJ (2013) Epigenetics of the depressed brain: role of histone acetylation and methylation. Neuropsychopharmacology 38:124–137
Szczepankiewicz A, Leszczynska-Rodziewicz A, Pawlak J, Narozna B, Rajewska-Rager A, Wilkosc M, Zaremba D, Maciukiewicz M, Twarowska-Hauser J (2014) FKBP5 polymorphism is associated with major depression but not with bipolar disorder. J Affect Disord 164:33–37
Tafet GE, Nemeroff CB (2016) The links between stress and depression: psychoneuroendocrinological, genetic, and environmental interactions. J Neuropsychiatry Clin Neurosci 28:77–88
Takahashi A, Flanigan ME, McEwen BS, Russo SJ (2018) Aggression, social stress, and the immune system in humans and animal models. Front Behav Neurosci 12:56
Teicher MH, Anderson CM, Polcari A (2012) Childhood maltreatment is associated with reduced volume in the hippocampal subfields CA3, dentate gyrus, and subiculum. Proc Natl Acad Sci U S A 109:E563–E572
Tennant C (2002) Life events, stress and depression: a review of recent findings. Aust N Z J Psychiatry 36:173–182
ter Heegde F, De Rijk RH, Vinkers CH (2015) The brain mineralocorticoid receptor and stress resilience. Psychoneuroendocrinology 52:92–110
Toh YL, Ng T, Tan M, Tan A, Chan A (2018) Impact of brain-derived neurotrophic factor genetic polymorphism on cognition: A systematic review. Brain Behav 8:e01009
Treadway MT, Waskom ML, Dillon DG, Holmes AJ, Park MTM, Chakravarty MM, Dutra SJ, Polli FE, Iosifescu DV, Fava M et al (2015) Illness progression, recent stress, and morphometry of hippocampal subfields and medial prefrontal cortex in major depression. Biol Psychiatry 77:285–294
Ttofi MM (2015) Adolescent bullying linked to depression in early adulthood. BMJ 350:h2694
Turecki G, Meaney MJ (2016) Effects of the social environment and stress on glucocorticoid receptor gene methylation: a systematic review. Biol Psychiatry 79:87–96
Tyrka AR, Ridout KK, Parade SH, Paquette A, Marsit CJ, Seifer R (2015) Childhood maltreatment and methylation of FK506 binding protein 5 gene (FKBP5). Dev Psychopathol 27:1637–1645
Uchida S, Hara K, Kobayashi A, Funato H, Hobara T, Otsuki K, Yamagata H, McEwen BS, Watanabe Y (2010) Early life stress enhances behavioral vulnerability to stress through the activation of REST4-mediated gene transcription in the medial prefrontal cortex of rodents. J Neurosci 30:15007–15018
Uher R (2014) Gene-environment interactions in common mental disorders: an update and strategy for a genome-wide search. Soc Psychiatry Psychiatr Epidemiol 49:3–14
Ulrich-Lai YM, Herman JP (2009) Neural regulation of endocrine and autonomic stress responses. Nat Rev Neurosci 10:397–409
van Bodegom M, Homberg JR, Henckens M (2017) Modulation of the hypothalamic-pituitary-adrenal axis by early life stress exposure. Front Cell Neurosci 11:87
Van den Bergh BR (2011) Developmental programming of early brain and behaviour development and mental health: a conceptual framework. Dev Med Child Neurol 53(Suppl 4):19–23
Van den Bergh BR, Mulder EJ, Mennes M, Glover V (2005) Antenatal maternal anxiety and stress and the neuro behavioural development of the fetus and child: links and possible mechanisms: a review. Neurosci Biobehav Rev 29:237–258
van Donkelaar EL, Vaessen KR, Pawluski JL, Sierksma AS, Blokland A, Canete R, Steinbusch HW (2014) Long-term corticosterone exposure decreases insulin sensitivity and induces depressive-like behaviour in the C57BL/6NCrl mouse. PLoS ONE 9:e106960
van Praag HM, de Kloet R, van Os J (2004) Stress, the brain and depression. Cambridge University Press
Verdolini N, Attademo L, Agius M, Ferranti L, Moretti P, Quartesan R (2015) Traumatic events in childhood and their association with psychiatric illness in the adult. Psychiatr Danub 27(Suppl 1):S60–S70
Vialou V, Feng J, Robison AJ, Nestler EJ (2013) Epigenetic mechanisms of depression and antidepressant action. Annu Rev Pharmacol Toxicol 53:59–87
Vijayendran M, Beach SR, Plume JM, Brody GH, Philibert RA (2012) Effects of genotype and child abuse on DNA methylation and gene expression at the serotonin transporter. Front Psychiatry 3:55
Vinberg M, Trajkovska V, Bennike B, Knorr U, Knudsen GM, Kessing LV (2009) The BDNF Val66Met polymorphism: relation to familiar risk of affective disorder, BDNF levels and salivary cortisol. Psychoneuroendocrinology 34:1380–1389
Vinkers CH, Joels M, Milaneschi Y, Kahn RS, Penninx BW, Boks MP (2014) Stress exposure across the life span cumulatively increases depression risk and is moderated by neuroticism. Depress Anxiety 31:737–745
Vinkers CH, Joels M, Milaneschi Y, Gerritsen L, Kahn RS, Penninx BW, Boks MP (2015) Mineralocorticoid receptor haplotypes sex-dependently moderate depression susceptibility following childhood maltreatment. Psychoneuroendocrinology 54:90–102
Wang SS, Mu RH, Li CF, Dong SQ, Geng D, Liu Q, Yi LT (2017) microRNA-124 targets glucocorticoid receptor and is involved in depression-like behaviors. Prog Neuropsychopharmacol Biol Psychiatry 79:417–425
Wang D, Szyf M, Benkelfat C, Provencal N, Turecki G, Caramaschi D, Cote SM, Vitaro F, Tremblay RE, Booij L (2012) Peripheral SLC6A4 DNA methylation is associated with in vivo measures of human brain serotonin synthesis and childhood physical aggression. PLoS ONE 7:e39501
Wankerl M, Wust S, Otte C (2010) Current developments and controversies: does the serotonin transporter gene-linked polymorphic region (5-HTTLPR) modulate the association between stress and depression? Curr Opin Psychiatry 23:582–587
Wasserman D, Wasserman J, Rozanov V, Sokolowski M (2009) Depression in suicidal males: genetic risk variants in the CRHR1 gene. Genes Brain Behav 8:72–79
Weder N, Zhang H, Jensen K, Yang BZ, Simen A, Jackowski A, Lipschitz D, Douglas-Palumberi H, Ge M, Perepletchikova F et al (2014) Child abuse, depression, and methylation in genes involved with stress, neural plasticity, and brain circuitry. J Am Acad Child Adolesc Psychiatry 53(417–424):e415
Weinstock M (2017) Prenatal stressors in rodents: effects on behavior. Neurobiol Stress 6:3–13
Williams SG, Langhinrichsen-Rohling J, Wornell C, Finnegan H (2017) Adolescents transitioning to high school: sex differences in bullying victimization associated with depressive symptoms, suicide ideation, and suicide Attempts. J Sch Nurs 33:467–479
Wolf OT (2017). Stress effects on learning and memory in humans. In: Fink G (ed) Stress: neuroendocrinology and neurobiology. Academic Press, pp 309–315
Wray NR, Pergadia ML, Blackwood DH, Penninx BW, Gordon SD, Nyholt DR, Ripke S, MacIntyre DJ, McGhee KA, Maclean AW et al (2012) Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned. Mol Psychiatry 17:36–48
Wust S, Van Rossum EF, Federenko IS, Koper JW, Kumsta R, Hellhammer DH (2004) Common polymorphisms in the glucocorticoid receptor gene are associated with adrenocortical responses to psychosocial stress. J Clin Endocrinol Metab 89:565–573
Xu J, Wang R, Liu Y, Liu D, Jiang H, Pan F (2017) FKBP5 and specific microRNAs via glucocorticoid receptor in the basolateral amygdala involved in the susceptibility to depressive disorder in early adolescent stressed rats. J Psychiatr Res 95:102–113
Xu H, Wang J, Zhang K, Zhao M, Ellenbroek B, Shao F, Wang W (2018) Effects of adolescent social stress and antidepressant treatment on cognitive inflexibility and Bdnf epigenetic modifications in the mPFC of adult mice. Psychoneuroendocrinology 88:92–101
Yang L, Zhao Y, Wang Y, Liu L, Zhang X, Li B, Cui R (2015) The effects of psychological stress on depression. Curr Neuropharmacol 13:494–504
Yang Y, Hu Z, Du X, Davies H, Huo X, Fang M (2017) miR-16 and fluoxetine both reverse autophagic and apoptotic change in chronic unpredictable mild stress model rats. Front Neurosci 11:428
Yin Q, Shang Z, Zhou N, Wu L, Liu G, Yu X, Zhang H, Xue H, Liu W (2018) An investigation of physical and mental health consequences among Chinese parents who lost their only child. BMC Psychiatry 18:45
You S, Conner KR (2009) Stressful life events and depressive symptoms: influences of gender, event severity, and depression history. J Nerv Ment Dis 197:829–833
Zanier-Gomes PH, de Abreu Silva TE, Zanetti GC, Benati ER, Pinheiro NM, Murta BM, Crema VO (2015) Depressive behavior induced by social isolation of predisposed female rats. Physiol Behav 151:292–297
Zhao X, Sun L, Sun YH, Ren C, Chen J, Wu ZQ, Jiang YH, Lv XL (2014) Association of HTR2A T102C and A-1438G polymorphisms with susceptibility to major depressive disorder: a meta-analysis. Neurol Sci 35:1857–1866
Zhao M, Chen L, Yang J, Han D, Fang D, Qiu X, Yang X, Qiao Z, Ma J, Wang L et al (2018) BDNF Val66Met polymorphism, life stress and depression: a meta-analysis of gene-environment interaction. J Affect Disord 227:226–235
Zheng Y, Fan W, Zhang X, Dong E (2016) Gestational stress induces depressive-like and anxiety-like phenotypes through epigenetic regulation of BDNF expression in offspring hippocampus. Epigenetics 11:150–162
Zhu S, Shi R, Wang J, Wang JF, Li XM (2014) Unpredictable chronic mild stress not chronic restraint stress induces depressive behaviours in mice. NeuroReport 25:1151–1155
Zimmermann P, Bruckl T, Nocon A, Pfister H, Binder EB, Uhr M, Lieb R, Moffitt TE, Caspi A, Holsboer F et al (2011) Interaction of FKBP5 gene variants and adverse life events in predicting depression onset: results from a 10-year prospective community study. Am J Psychiatry 168:1107–1116
Zurawek D, Kusmider M, Faron-Gorecka A, Gruca P, Pabian P, Solich J, Kolasa M, Papp M, Dziedzicka-Wasylewska M (2017) Reciprocal MicroRNA expression in mesocortical circuit and its interplay with serotonin transporter define resilient rats in the chronic mild stress. Mol Neurobiol 54:5741–5751
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Ding, Y., Dai, J. (2019). Advance in Stress for Depressive Disorder. In: Fang, Y. (eds) Depressive Disorders: Mechanisms, Measurement and Management. Advances in Experimental Medicine and Biology, vol 1180. Springer, Singapore. https://doi.org/10.1007/978-981-32-9271-0_8
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