Abstract
Probiotics are live microorganisms like bacteria and yeast that are consumed along with food for various health benefits. These microorganisms play a very important role not only in intestinal microbial balance but also in maintaining health protection of the host organism against harmful microbiota. Probiotic term means “for life.” The sale of these products has increased worldwide, and sale figures are estimated to cross $45B by the year 2018 due to its wide range of health profits. Humans have used probiotics for decades and centuries involuntarily. Food additives like fermented milk and yogurt have been a major part in regular meals and diet in several parts of the world. Nowadays, probiotics are the most important prescription by gastrointestinal physicians’ because of its potential role in curing certain diseases for which treatment options are limited. The use of probiotics that were initially restricted for antibiotic-associated diarrhea now extends as powerful anti-allergic and anti-inflammatory factors. Lactobacillus and Bifidobacterium are the most important probiotic groups; however, the probiotic potential of Pediococcus, Lactococcus, Bacillus, and yeast is also well known. Probiotics are not only used as food to enhance health but also to cure specific gastrointestinal conditions such as irritable bowel syndrome, inflammatory bowel disease (IBD), and infectious diarrhea (caused by viruses, bacteria, or parasites). They also play an important role in improving skin conditions like eczema. Urinary and vaginal health, allergy prevention, colds, and oral health can be treated with probiotics. This chapter throws light on different probiotics, their health benefits, and regulatory or safety issues linked with their usage.
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References
Ozen M, Dinleyici EC (2015) The history of probiotics: the untold story. Benefic Microbes 6(2):159–165
Gogineni VK et al (2013) Probiotics: history and evolution. J Anc Dis Prev Remedies. https://doi.org/10.4172/2329-8731.1000107
Muller M (1900) Sacred books of the east. The Colonial Press, New York
Breasted J (1906) Ancient records of Egypt. University of Chicago Press, Chicago
Langdon A, Crook N, Dantas G (2016) The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation. Genome Med 8(1):39
Grice EA, Segre JA (2012) The human microbiome: our second genome. Annu Rev Genomics Hum Genet 13:151–170
Fijan S (2014) Microorganisms with claimed probiotic properties: an overview of recent literature. Int J Environ Res Public Health 11(5):4745–4767
Gill HS, Guarner F (2004) Probiotics and human health: a clinical perspective. Postgrad Med J 80(947):516–526
Rodriguez JM et al (2015) The composition of the gut microbiota throughout life, with an emphasis on early life. Microb Ecol Health Dis 26:26050
Yang I et al (2016) The infant microbiome: implications for infant health and neurocognitive development. Nurs Res 65(1):76–88
Bergonzelli GE et al (2005) Probiotics as a treatment strategy for gastrointestinal diseases? Digestion 72(1):57–68
Khailova L et al (2013) Probiotic administration reduces mortality and improves intestinal epithelial homeostasis in experimental sepsis. Anesthesiology 119(1):166–177
Prakash S et al (2014) Probiotics for the prevention and treatment of allergies, with an emphasis on mode of delivery and mechanism of action. Curr Pharm Des 20(6):1025–1037
Ooi LG, Liong MT (2010) Cholesterol-lowering effects of probiotics and prebiotics: a review of in vivo and in vitro findings. Int J Mol Sci 11(6):2499–2522
Kumar R, Dhanda S (2017) Mechanistic insight of probiotics derived anticancer pharmaceuticals: a road forward for cancer therapeutics. Nutr Cancer 69:1–6
Sinagra E et al (2013) Probiotics, prebiotics and symbiotics in inflammatory bowel diseases: state-of-the-art and new insights. J Biol Regul Homeost Agents 27(4):919–933
Shaukat A et al (2010) Systematic review: effective management strategies for lactose intolerance. Ann Intern Med 152(12):797–803
Brown AC, Valiere A (2004) Probiotics and medical nutrition therapy. Nutr Clin Care 7(2):56–68
Liaskovskii TM, Podgorskii VS (2005) Assessment of probiotics according to the international organizations (FAO/WHO). Mikrobiol Z 67(6):104–112
Soccol CR et al (2010) The potential of probiotics: a review. Food Technol Biotechnol 48(4):413–434
Gomes AM, Malcata FX (1999) Bifidobacterium spp. and Lactobacillus acidophilus: biological, biochemical, technological and therapeutical properties relevant for use as probiotics. Trends Food Sci Technol 10(4):139–157
Dembele T, Obdrzalek V, Votava M (1998) Inhibition of bacterial pathogens by lactobacilli. Zentralbl Bakteriol 288(3):395–401
Gibson GR et al (1995) Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin. Gastroenterology 108(4):975–982
Bermudez-Brito M et al (2012) Probiotic mechanisms of action. Ann Nutr Metab 61(2):160–174
Ouwehand AC (2016) A review of dose-responses of probiotics in human studies. Benefic Microbes 8:1–10
Ritchie ML, Romanuk TN (2012) A meta-analysis of probiotic efficacy for gastrointestinal diseases. PLoS One 7(4):e34938. Epub 2012 Apr 18
Cruchet S et al (2015) The use of probiotics in pediatric gastroenterology: a review of the literature and recommendations by Latin-American experts. Paediatr Drugs 17(3):199–216
Goldenberg SD (2016) Faecal microbiota transplantation for recurrent Clostridium difficile infection and beyond: risks and regulation. J Hosp Infect 92(2):115–116
McFarland LV (2015) Deciphering meta-analytic results: a mini-review of probiotics for the prevention of paediatric antibiotic-associated diarrhoea and Clostridium difficile infections. Benefic Microbes 6(2):189–194
Aceti A et al (2015) Probiotics for prevention of necrotizing enterocolitis in preterm infants: systematic review and meta-analysis. Ital J Pediatr 41:89
Savaiano DA (2014) Lactose digestion from yogurt: mechanism and relevance. Am J Clin Nutr 99(5 Suppl):1251s–1255s
Korada SK et al (2016) Can probiotics cure inflammatory bowel diseases? Curr Pharm Des 22(7):904–917
Drouault-Holowacz S et al (2008) A double blind randomized controlled trial of a probiotic combination in 100 patients with irritable bowel syndrome. Gastroenterol Clin Biol 32(2):147–152
Faruqui AA, Jamaiwar B, Sharma B (2017) Combination of bulk laxative along with probiotics and prebiotics in the management of irritable bowel syndrome with constipation: a safe & effective option. Asian J Med Sci 8(1):6
Vaishnavi C (2013) Translocation of gut flora and its role in sepsis. Indian J Med Microbiol 31(4):334–342
Slattery J, MacFabe DF, Frye RE (2016) The significance of the enteric microbiome on the development of childhood disease: a review of prebiotic and probiotic therapies in disorders of childhood. Clin Med Insights Pediatr 10:91–107
Lim IS, Lee HS, Kim WY (2009) The effect of lactic acid bacteria isolates on the urinary tract pathogens to infants in vitro. J Korean Med Sci 24(Suppl):S57–S62
Saber A et al (2017) Cellular and molecular effects of yeast probiotics on cancer. Crit Rev Microbiol 43(1):96–115
Chong ES (2014) A potential role of probiotics in colorectal cancer prevention: review of possible mechanisms of action. World J Microbiol Biotechnol 30(2):351–374
Liong MT (2008) Roles of probiotics and prebiotics in colon cancer prevention: postulated mechanisms and in-vivo evidence. Int J Mol Sci 9(5):854–863
Pericleous M, Mandair D, Caplin ME (2013) Diet and supplements and their impact on colorectal cancer. J Gastrointest Oncol 4(4):409–423
Link-Amster H et al (1994) Modulation of a specific humoral immune response and changes in intestinal flora mediated through fermented milk intake. FEMS Immunol Med Microbiol 10(1):55–63
Sgouras DN, Trang TT, Yamaoka Y (2015) Pathogenesis of Helicobacter pylori infection. Helicobacter 20(Suppl 1):8–16
Sgouras D et al (2004) In vitro and In vivo inhibition of Helicobacter pylori by Lactobacillus casei strain Shirota. Appl Environ Microbiol 70(1):518–526
Kumar M et al (2012) Cholesterol-lowering probiotics as potential biotherapeutics for metabolic diseases. Exp Diabetes Res 2012:902917
Lye HS et al (2009) The improvement of hypertension by probiotics: effects on cholesterol, diabetes, renin, and phytoestrogens. Int J Mol Sci 10(9):3755–3775
Yarandi SS et al (2016) Modulatory effects of gut microbiota on the central nervous system: how gut could play a role in neuropsychiatric health and diseases. J Neurogastroenterol Motil 22(2):201–212
Rao AV et al (2009) A randomized, double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome. Gut Pathog 1(1):6
Degnan FH (2008) The US Food and Drug Administration and probiotics: regulatory categorization. Clin Infect Dis 46(Suppl 2): S133–S136; discussion S144-51.
ICMR-DBT guidelines for evaluation of probiotics in food (2011) Indian J Med Res 134:22–25
Market RA (2016) Probiotics Market by Ingredient (Bacteria, Yeast), Application (Food & Beverages, Dietary Supplements, Animal Feed), Function (Regular, Preventative Healthcare, Therapeutic) – Global Opportunity Analysis and Industry Forecast, 2014 – 2022
Hoffman FA et al (2008) Executive summary: scientific and regulatory challenges of development of probiotics as foods and drugs. Clin Infect Dis 46(Suppl 2):S53–S57
Flynn A (2012) Scientific substantiation of health claims in the EU. Proc Nutr Soc 71(1):120–126
Sreeja V, Prajapati JB (2013) Probiotic formulations: application and status as pharmaceuticals—a review. Probiotics and Antimicrobial Proteins 5(2):81–91
Redman MG, Ward EJ, Phillips RS (2014) The efficacy and safety of probiotics in people with cancer: a systematic review. Ann Oncol 25(10):1919–1929
Goldenberg JZ et al (2015) Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev 12:Cd004827
Lv Z et al (2015) Efficacy and safety of probiotics as adjuvant agents for Helicobacter pylori infection: a meta-analysis. Exp Ther Med 9(3):707–716
Yan Q, Li X, Feng B (2015) The efficacy and safety of probiotics intervention in preventing conversion of impaired glucose tolerance to diabetes: study protocol for a randomized, double-blinded, placebo controlled trial of the Probiotics Prevention Diabetes Programme (PPDP). BMC Endocr Disord 15:74
Xu M et al (2015) The efficacy and safety of the probiotic Bacterium Lactobacillus reuteri DSM 17938 for Infantile Colic: a meta-analysis of randomized controlled trials. PLoS One 10(10):e0141445
Sanders ME, Levy DD (2011) The science and regulations of probiotic food and supplement product labeling. Ann N Y Acad Sci 1219(Suppl 1):E1–e23
Hemarajata P, Versalovic J (2013) Effects of probiotics on gut microbiota: mechanisms of intestinal immunomodulation and neuromodulation. Therap Adv Gastroenterol 6(1):39–51
Didari T et al (2014) A systematic review of the safety of probiotics. Expert Opin Drug Saf 13(2):227–239
Acknowledgments
The authors would like to acknowledge CSIR-CDRI for infrastructure and other support necessary for writing the book chapter. TJ would like to thank CSIR for his junior and senior research fellowships. The manuscript bears the CDRI communication number 9484.
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Banerjee, D., Jain, T., Bose, S., Bhosale, V. (2018). Importance of Probiotics in Human Health. In: Rani, V., Yadav, U. (eds) Functional Food and Human Health. Springer, Singapore. https://doi.org/10.1007/978-981-13-1123-9_23
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DOI: https://doi.org/10.1007/978-981-13-1123-9_23
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