Tracing the Early Cell Divisions of Mouse Embryos by Single Cell RNA-Seq

The identity and function of a cell is determined by its entire RNA component, which is called the transcriptome of a cell. The transcriptome is the functional readout of the genome and epigenome. In an organism, essentially every cell has the same genome, while every cell type and potentially each individual cell has a unique transcriptome. Ideally, the transcriptome analysis should capture the exact quantity of all full length RNAs of all classes at single-base resolution in the smallest functional unit of an organism, an individual cell.

Authors and Affiliations

1. Life Technologies, Genetic Systems, 850 Lincoln Centre Dr, Foster City, CA, 94404, USA

   Catalin Barbacioru

Editors and Affiliations

1. School of Biology, Department of Biomedical Engineering and College of Computing, Georgia Institute of Technology, Atlanta, Georgia, USA

   Mark Borodovsky

2. Molecular and Cell Biology Department, University of Connecticut, 91 North Eagleville Road, Unit 3125, 06269-3125, Storrs, CT, USA

   Johann Peter Gogarten

3. National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Building 38A 8S814, 20894, Bethesda, MD, USA

   Teresa M. Przytycka

4. Department of Computer Science and Engineering, University of Connecticut, 257 ITE Building, 371 Fairfield Way, 06269-2155, Storrs, CT, USA

   Sanguthevar Rajasekaran

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