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Controllable photodynamic performance via an acidic microenvironment based on two-dimensional metal-organic frameworks for photodynamic therapy

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Abstract

Photodynamic therapy (PDT) is a widely-used technology for cancer therapy, but conventional photosensitizers still face some drawbacks, such as hydrophobicity, inadequate pharmacokinetics, low cell/tissue specificity, and uncontrollable photodynamic performance during the therapeutic process. Herein, we present a controllable photodynamic performance based on two-dimensional metal-organic frameworks (2D Zn-TCPP MOF) that displayed a week PDT effect under a neutral environment upon exposure to a 660 nm laser due to the degeneracy of Q bands of TCPP. However, the 2D Zn-TCPP MOF showed a significantly enhanced PDT effect in an acidic environment under irradiation with a 660 nm laser due to the released TCPP from decomposed MOF structure. From the in vitro outcomes, the 2D Zn-TCPP MOF showed controllable photodynamic performance from neutral to acidic environments. Due to the acidic tumor microenvironment, the 2D Zn-TCPP MOF presented the strongest antitumor effect in vivo under irradiation with a 660 nm laser. This work offers a promising strategy to develop a next-generation photosensitizer.

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Acknowledgements

This work is supported by the National Natural Science Foundation of China (NSFC) (Nos. 51903162 and U1903120) and Science foundation of Guangdong Second Provincial General Hospital (No. YN2018-001).

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Author notes

  1. Tao Zhang

    Present address: Present address: School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore, 637371, Singapore

Authors and Affiliations

  1. The Department of Medical Imaging Guangdong Second Provincial General Hospital, Guangzhou, 518037, China

    Lifeng Hang, Hua Wen, Lianbao Liang, Wuming Li, Xiaofen Ma & Guihua Jiang

  2. The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 518037, China

    Guihua Jiang

  3. University of Science and Technology of China, Hefei, 230027, China

    Tao Zhang

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  1. Lifeng Hang
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  2. Tao Zhang
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Correspondence to Lifeng Hang or Guihua Jiang.

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Controllable photodynamic performance via an acidic microenvironment based on two-dimensional metal-organic frameworks for photodynamic therapy

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Hang, L., Zhang, T., Wen, H. et al. Controllable photodynamic performance via an acidic microenvironment based on two-dimensional metal-organic frameworks for photodynamic therapy. Nano Res. 14, 660–666 (2021). https://doi.org/10.1007/s12274-020-3093-1

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