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Computational Modelling of Protein Complex Structure and Assembly

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Protein Complex Assembly

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1764))

Abstract

Sequence and structure space are nowadays sufficiently large that we can use computational methods to model the structure of proteins based on sequence similarity alone. Not only useful as a standalone tool, homology modelling has also had a transformative effect on the ease with which we can solve crystal structures and electron density maps. Another technique—molecular dynamics—aims to model protein structures from first principles and, thanks to increases in computational power, is slowly becoming a viable tool for studying protein complexes. Finally, the prediction of protein assembly pathways from three-dimensional structures of complexes is also now becoming possible.

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Acknowledgment

J.M. is supported by a Medical Research Council Career Development Award (MR/M02122X/1).

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Authors and Affiliations

  1. MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK

    Jonathan N. Wells, L. Therese Bergendahl & Joseph A. Marsh

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  1. Jonathan N. Wells
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  2. L. Therese Bergendahl
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  3. Joseph A. Marsh
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Corresponding author

Correspondence to Jonathan N. Wells .

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Editors and Affiliations

  1. MRC Human Genetics Unit, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

    Joseph A. Marsh

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Wells, J.N., Bergendahl, L.T., Marsh, J.A. (2018). Computational Modelling of Protein Complex Structure and Assembly. In: Marsh, J. (eds) Protein Complex Assembly. Methods in Molecular Biology, vol 1764. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7759-8_22

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  • DOI: https://doi.org/10.1007/978-1-4939-7759-8_22

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