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Oxidative Damages to Eye Stem Cells, in Response to, Bright and Ultraviolet Light, Their Associated Mechanisms, and Salvage Pathways

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Abstract

The surface of the eye is continuously exposed to the harshness of the external environment. As a homeostatic mechanism for replenishing the worn off cells of the ocular surface, a balance is maintained via the role of ocular stem cells. However, under extreme conditions of harshness like exposure to bright and ultraviolet light, the ocular stem cells are unable to do the repair mechanisms resulting in severe impairment of vision and disturbances in the eye. This work reappraises the recent understandings of mechanisms of oxidative damages caused to the ocular stem cells by UV/bright light and their probable mitigation.

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Acknowledgements

The authors would like to thank Mr. Utsav Sen Ph.D. student in Yenepoya research centre, Yenepoya University for his help in art work.

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  1. Stem Cells and Regenerative Medicine Centre, Yenepoya Research Centre, Yenepoya (Deemed to be University), University Road, Derlakatte, Mangalore, Karnataka, 575018, India

    Bipasha Bose & Sudheer Shenoy P

  2. College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, 11671, Kingdom of Saudi Arabia

    Najwa Abdur Rashid

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  1. Bipasha Bose
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Correspondence to Bipasha Bose or Sudheer Shenoy P.

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Bose, B., Najwa, A. & Shenoy P, S. Oxidative Damages to Eye Stem Cells, in Response to, Bright and Ultraviolet Light, Their Associated Mechanisms, and Salvage Pathways. Mol Biotechnol 61, 145–152 (2019). https://doi.org/10.1007/s12033-018-0136-x

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