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The Role of Inflammation in the Development of Diabetic Polyneuropathy and the Potential for Its Correction

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Objectives. To study the efficacy of the drug Cytoflavin in patients with diabetic polyneuropathy (DPN) by assessing the blood tumor necrosis factor-α (TNF-α) concentration. Materials and methods. An open, comparative, prospective observation of patients with a history of DPN for more than five years and high blood TNF-α levels was carried out. All patients received basic oral combined hypoglycemic therapy; patients in group 1 received Cytoflavin (10 ml per 200 ml 0.9% sodium chloride i.v.) for 10 days, followed by switching to oral Cytoflavin, 2 tablets twice a day for one month. The main indication for the use of Cytoflavin was the presence of cerebrovascular disease in all the patients studied. The severity of the clinical manifestations of DPN and patients’ quality of life (QoL) were assessed, and TNF-α levels were determined as an indicator of inflammation. Results. Cytoflavin use was associated with increases in quality of life indicators, decreases in the severity of sensory disturbances, and decreases in TNF-α levels, which may indicate a possible anti-inflammatory mechanism of action for this drug. Conclusions. Use of Cytoflavin can inhibit inflammation and reduce the severity of sensory disorders in patients with DPN.

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References

  1. Maffi, P. and Secchi, A., “The burden of diabetes: Emerging data,” Dev. Ophthalmol., 60, No. 6, 1–5 (2017).

    PubMed  Google Scholar 

  2. Liu, X., Xu, Y., An, M., and Zeng, Q., “The risk factors for diabetic peripheral neuropathy: a meta-analysis,” PLoS One, 14, No. 2, e0212574 (2019).

    Google Scholar 

  3. Dedov, I. I., Shestakova, M. V., and Vikulova, O. K., “State Diabetes Mellitus Register of the Russian Federation: Status in 2014 and prospects for development,” Sakhar. Diabet, 18, No. 3, 5–23 (2015).

    Google Scholar 

  4. Callaghan, B. C., Cheng, H. T., et al., “Diabetic neuropathy: clinical manifestations and current treatments,” Lancet Neurol., 11, No. 6, 521–534 (2012).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Zubair, M. and Ahmad, J., “Role of growth factors and cytokines in diabetic foot ulcer healing: A detailed review,” Rev. Endocr. Metab. Disord., 20, No. 2, 207–217 (2019).

    Article  PubMed  Google Scholar 

  6. Kartika, R. W., Alwi, I., Suyatna, F. D., et al., “The role of VEGF, PDGF, and IL-6 on diabetic foot ulcer after platelet rich fibrin + hyaluronic therapy,” Heliyon, 7, No. 9, e07934 (2021).

    Google Scholar 

  7. Várkonyi, T., Körei, A., Putz, Z., et al., “Advances in the management of diabetic neuropathy,” Minerva Med., 108, No. 5, 419–437 (2017).

    Article  PubMed  Google Scholar 

  8. Thakur, V., Sadanandan, J., and Chattopadhyay, M., “High-mobility group box 1 protein signaling in painful diabetic neuropathy,” Int. J. Mol. Sci., 21, No. 3, 881 (2020).

  9. Davydov, O. S., Yakhno, N. N., Kukushkin, M. L., et al., Neuropathic Pain. Clinical Guidelines for Diagnosis and Treatment, Russian Association for the Study of Pain, Moscow (2018), pp. 1–88.

  10. Khramilin, V. N. and Demidova, I. Yu., “Features of the diagnosis and treatment of diabetic polyneuropathy in elderly patients,” Effektiv. Farmakoter., 16, No. 12, 42–54 (2020).

    Google Scholar 

  11. Attal, N., “Pharmacological treatments of neuropathic pain: The latest recommendations,” Rev. Neurol (Paris), 175, No. 1–2, 46–50 (2019).

    Article  PubMed  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Novosibirsk State Medical University, Russian Ministry of Health, Novosibirsk, Russia

    L. A. Shchepankevich, M. A. Pervuninskaya, I. A. Gribacheva, T. F. Popova, E. V. Petrova & M. S. Shchepankevich

  2. Federal Research Center for Basic and Translational Medicine, Novosibirsk, Russia

    L. A. Shchepankevich, M. A. Pervuninskaya & Yu. A. Nicolaev

  3. State Novosibirsk Regional Clinical Hospital, Novosibirsk, Russia

    L. A. Shchepankevich & E. V. Taneeva

Authors
  1. L. A. Shchepankevich
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  2. M. A. Pervuninskaya
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  3. I. A. Gribacheva
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  4. T. F. Popova
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  5. Yu. A. Nicolaev
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  6. E. V. Taneeva
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  7. E. V. Petrova
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  8. M. S. Shchepankevich
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Correspondence to L. A. Shchepankevich.

Additional information

Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 123, No. 4, pp. 68–71, April, 2023.

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Shchepankevich, L.A., Pervuninskaya, M.A., Gribacheva, I.A. et al. The Role of Inflammation in the Development of Diabetic Polyneuropathy and the Potential for Its Correction. Neurosci Behav Physi 53, 1373–1376 (2023). https://doi.org/10.1007/s11055-023-01528-z

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  • DOI: https://doi.org/10.1007/s11055-023-01528-z

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