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Implications of flavonoids as potential modulators of cancer neovascularity

  • Review – Cancer Research
  • Published:
Journal of Cancer Research and Clinical Oncology Aims and scope Submit manuscript

Abstract

Purpose

The formation of new blood vessels from previous ones, angiogenesis, is critical in tissue repair, expansion or remodeling in physiological processes and in various pathologies including cancer. Despite that, the development of anti-angiogenic drugs has great potential as the treatment of cancer faces many problems such as development of the resistance to treatment or an improperly selected therapy approach. An evaluation of predictive markers in personalized medicine could significantly improve treatment outcomes in many patients.

Methods

This comprehensive review emphasizes the anticancer potential of flavonoids mediated by their anti-angiogenic efficacy evaluated in current preclinical and clinical cancer research.

Results and conclusion

Flavonoids are important groups of phytochemicals present in common diet. Flavonoids show significant anticancer effects. The anti-angiogenic effects of flavonoids are currently a widely discussed topic of preclinical cancer research. Flavonoids are able to regulate the process of tumor angiogenesis through modulation of signaling molecules such as VEGF, MMPs, ILs, HIF or others. However, the evaluation of the anti-angiogenic potential of flavonoids within the clinical studies is not frequently discussed and is still of significant scientific interest.

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Funding

The Qatar National Library funded the publication of this article. This work is supported by the Scientific Grant Agency of the Ministry of Education of the Slovak Republic under the contracts no. VEGA 1/0136/19 and the Slovak Research and Development Agency under the contract no. APVV-16-0021. This publication is the result of the project implementation: "CENTER OF EXCELLENCE FOR RESEARCH IN PERSONALIZED THERAPY (CEVYPET)", ITMS: 26220120053 supported by the Operational Programme Research and Innovation funded by the ERDF.

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Authors and Affiliations

  1. Clinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia

    Alena Liskova, Lenka Koklesova, Marek Samec & Kamil Biringer

  2. Department of Physiology and Biophysics, Weill Cornell Medicine in Qatar, Education City, Qatar Foundation, Doha, 24144, Qatar

    Elizabeth Varghese, Mariam Abotaleb, Samson Mathews Samuel & Dietrich Büsselberg

  3. Department of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic

    Karel Smejkal

  4. Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia

    Martin Petras

  5. Department of Biology and Ecology, Faculty of Education, Catholic University in Ruzomberok, Ruzomberok, Slovakia

    Dana Blahutova

  6. Lambda Life JSC., Bratislava, Slovakia

    Ondrej Bugos

  7. Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 036 01, Martin, Slovakia

    Martin Pec & Peter Kubatka

  8. Department of Histology and Embryology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia

    Marian Adamkov

  9. Gastroenterology Unit, Department of Medicine, Azienda Ospedaliera Universitaria Integrata Policlinico GB Rossi, University of Verona, Verona, Italy

    Rachele Ciccocioppo

  10. Department of Thoracic Surgery, Faculty of Medicine and Dentistry, Medical University of Silesia, Katowice, Poland

    Mariusz Adamek

  11. Faculty of Medicine, University of Oviedo, Central University Hospital of Asturias (HUCA), Oviedo, Spain

    Luis Rodrigo

  12. 1st Department of Internal Medicine, Faculty of Medicine, Comenius University and University Hospital, Bratislava, Slovakia

    Martin Caprnda

  13. 2nd Department of Surgery, Faculty of Medicine, Masaryk University, Pekarska 53, 656 91, Brno, Czech Republic

    Peter Kruzliak

  14. St. Anne’s University Hospital, Brno, Czech Republic

    Peter Kruzliak

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  1. Alena Liskova
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  2. Lenka Koklesova
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  3. Marek Samec
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  17. Luis Rodrigo
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  18. Martin Caprnda
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  19. Peter Kruzliak
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  20. Peter Kubatka
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Corresponding authors

Correspondence to Dietrich Büsselberg, Peter Kruzliak or Peter Kubatka.

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Liskova, A., Koklesova, L., Samec, M. et al. Implications of flavonoids as potential modulators of cancer neovascularity. J Cancer Res Clin Oncol 146, 3079–3096 (2020). https://doi.org/10.1007/s00432-020-03383-8

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