[go: up one dir, main page]
More Web Proxy on the site http://driver.im/ Skip to main content

Advertisement

Springer Nature Link
Log in

Synthesis and characterization of macroporous sodium alginate-g-poly(AA-co-DMAPMA) hydrogel

  • Original Paper
  • Published:
Polymer Bulletin Aims and scope Submit manuscript

Abstract

In this manuscript, the novel sodium alginate-g-poly [acrylic acid–N-(3-dimethylaminopropyl) methyl acrylamide] [NaAlg-g-P(AA-co-DMAPMA)] hydrogel was prepared using free radical polymerization. Fourier transform infrared spectroscopy (FT-IR), thermogravimetry (TG), point zero charge and scanning electron microscopy were used to investigate the structure, thermal stability, surface charge and microstructure of the hydrogel. The factors that affected the swelling ratio of the hydrogel were investigated in detail, such as pH and ionic strength; the results showed that the hydrogel has a favorable pH-sensitive property. To investigate drug loading and sustained release of NaAlg-g-P(AA-co-DMAPMA), rhodamine B as a model drug was loaded on NaAlg-g-P(AA-co-DMAPMA). The in vitro drug release study conducted at pH 1.86 and 6.86 shows that NaAlg-g-P(AA-co-DMAPMA) was suitable for colon-specific drug delivery systems.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
£29.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (United Kingdom)

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10
Fig. 11

Similar content being viewed by others

Explore related subjects

Discover the latest articles, news and stories from top researchers in related subjects.

References

  1. Jaiswai M, Koul V (2013) Assessment of multicomponent hydrogel scaffolds of poly(acrylic acid-2-hydroxy ethyl methacrylate)/gelatin for tissue engineering applications. J Biomater Appl 27:848–861

    Article  Google Scholar 

  2. Yin W, Su R, Qi W, He Z (2012) A casein-polysaccharide hybrid hydrogel cross-linked by transglutaminase for drug delivery. J Mater Sci 47:2045–2055

    Article  CAS  Google Scholar 

  3. Biswas CS, Sulu E, Hazer B (2015) Effect of the composition of methanol-water mixtures on tacticity of poly (N-ethylacrylamide) gel. J Appl Polym Sci 132:41668–41678

    Google Scholar 

  4. Khademhosseini A, Langer R (2007) Review: microengineered hydrogel for tissue engineering. Biomaterials 28:5087–5092

    Article  CAS  Google Scholar 

  5. Biswas CS, Hazer B (2015) Synthesis and characterization of stereoregular poly(N-ethylacrylamide) hydrogel by using Y(OTf)3 Lewis acid. Colloid Polym Sci 293:143–152

    Article  CAS  Google Scholar 

  6. Şanal T, Oruç O, Öztürk T, Hazer B (2015) Synthesis of pH- and Thermo-responsive Poly(ε-Caprolactone-b-4-vinyl benzyl-g-dimethyl amino ethyl methacrylate) Brush Graft Copolymers via RAFT Polymerization. J Polym Res 22(3):1–12

    Google Scholar 

  7. Jaiswal M, Gupta A, Dinda AK, Koul V (2010) Polycaprolactone diacrylate (PCL-DAr) crosslinked biodegradable semi-interpenetrating networks (semi-IPNs) of polyacrylamide and gelatin for controlled drug delivery. Biomed Mater 5:065014

    Article  Google Scholar 

  8. Shamunga Sudar S, Sangeetha D (2012) Investigation on sulphonated PEEK beads for drug delivery, bioactivity and tissue engineering applications. J Mater Sci 47:2736–2742

    Article  Google Scholar 

  9. Rajesh N, Siddaramaiah (2009) Feasibility of xanthan gum–sodium alginate as a transdermal drug delivery system for domperidone. J Mater Sci Mater Med 20(10):2085–2089

    Article  CAS  Google Scholar 

  10. Agnihotri SA, Kulkarni RV, Nadagouda NM, Kulkarni PV, Aminabhavi TM (2005) Electrically modulated transport of diclofenac salts through hydrogel of sodium alginate, carbopol, and their blend polymers. J Appl Polym Sci 96(2):301–311

    Article  CAS  Google Scholar 

  11. Hua S, Ma H, Li X, Yang H, Wang A (2010) pH-sensitive sodium alginate/poly(vinyl alcohol) hydrogel beads prepared by combined Ca2+ crosslinking and freeze-thawing cycles for controlled release of diclofenac sodium. Int J Biol Macromol 46(5):517–523

    Article  CAS  Google Scholar 

  12. Bagheri Marandi G, Sharifnia N, Hosseinzadeh H (2006) Synthesis of an alginate- poly(sodium acrylate-co-acrylamide) superabsorbent hydrogel with low salt sensitivity and high pH sensitivity. J Appl Polym Sci 101:2927–2937

    Article  Google Scholar 

  13. Lang YY, Jiang TY, Li SM, Zheng LY (2008) Study on physicochemical properties of thermosensitive hydrogel constructed using graft-copolymers of poly(N-iso- propylacrylamide) and guar gum. J Appl Polym Sci 108(6):3473–3479

    Article  CAS  Google Scholar 

  14. Gao CM, Liu MZ, Chen J, Chen C (2012) pH- and temperature-responsive P(DMAEMA-GMA)-Alginate semi-IPN hydrogel formed by radical and ring- opening polymerization for aminophylline release. J Biomat Sci Polym E 23:1039–1054

    Article  CAS  Google Scholar 

  15. Demirel GB, Caykara T, Demiray M, Gürü M (2009) Effect of pore-forming agent type on swelling properties of macroporous poly(N-[3-(dimethylaminopropyl)]-methacrylamide-co-acrylamide) hydrogel. J Macromol Sci Part A Pure Appl Chem 46:58–64

    Article  CAS  Google Scholar 

  16. Mall ID, Srivastava VC, Kumar GVA, Mishra IM (2006) Characterization and utilization of mesoporous fertilizer plant waste carbon for adsorptive removal of dyes from aqueous solution. Colloid Surf A 278:175–187

    Article  CAS  Google Scholar 

  17. Kulkarni RV, Sreedhar V, Mutalik S, Setty CM, Sa B (2010) Interpenetrating network hydrogel membranes of sodium alginate and poly(vinyl alcohol) for controlled release of prazosin hydrochloride through skin. Int J Biol Macromol 47:520–527

    Article  CAS  Google Scholar 

  18. Zhou C, Wu Q (2011) A novel polyacrylamide nanocomposite hydrogel reinforced with natural chitosan nanofibers. Colloids Surf B 84:155–162

    Article  CAS  Google Scholar 

  19. Pachuaua L, Mazumder B (2012) Albizia procera gum as an excipient for oral controlled release matrix tablet. Carbohydr Polym 90:289–295

    Article  Google Scholar 

  20. Wang XF, Sun XW, Liu WX, Gong BY, Gao NB (2008) Chitosan hydrogel beads for fulvic acid adsorption: behaviors and mechanisms. Chem Eng J 142:239–247

    Article  CAS  Google Scholar 

  21. Pechenyuk SI (1999) The use of the pH at the point of zero charge for characterizing the properties of oxide hydroxides. Russ Chem B 48:1017–1023

    Article  CAS  Google Scholar 

  22. Buchholz FL, Fredric L, Peppas NA (eds) (1994) Superabsorbent polymers: science and technology: developed from a symposium sponsored by the division of polymeric materials: science and engineering. ACS Symposium Series 573. American Chemical Society, Washington, DC

  23. Kasgoz H, Durmus A (2008) Dye removal by a novel hydrogel-clay nanocomposite with enhanced swelling properties. Polym Adv Technol 19:838–845

    Article  CAS  Google Scholar 

  24. Gao TP, Wang WB, Wang AQ (2011) A pH-sensitive composite hydrogel based on sodium alginate and medical stone: synthesis, swelling, and heavy metal ions adsorption properties. Macromol Res 19(7):739–748

    Article  CAS  Google Scholar 

  25. Park SE, Nho YC, Lim YM, Kim H (2004) Preparation of pH-sensitive poly(vinyl alcohol-g-methacrylic acid) and poly(vinyl alcohol-g-acrylic acid) hydrogel by gamma ray irradiation and their insulin release behavior. J Appl Polym Sci 91:636–643

    Article  CAS  Google Scholar 

Download references

Acknowledgments

This work has been supported by the Youthful National Science Foundation of Hubei (No. 2014CFB618); the Open Science Foundation of Key Laboratory of Biological Resources Protection and Utilization of Hubei Province (No. PKLHB1511); the Science Research Group of Hubei University for Nationalities (MY2014T007, MY2013T004); the Doctoral Science Research Foundation of Hubei University for Nationalities (MY2013B017).

Author information

Authors and Affiliations

  1. Key Laboratory of Biologic Resources Protection and Utilization of Hubei Province, Enshi, Hubei, 445000, China

    Chengyi Wu

  2. Department of Chemistry and Environmental Engineering, Hubei University of Nationalities, Enshi, Hubei, 445000, China

    Chengyi Wu, Dandan Wang, Huimin Wu & Youmeng Dan

Authors
  1. Chengyi Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dandan Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Huimin Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Youmeng Dan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Chengyi Wu.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wu, C., Wang, D., Wu, H. et al. Synthesis and characterization of macroporous sodium alginate-g-poly(AA-co-DMAPMA) hydrogel. Polym. Bull. 73, 3255–3269 (2016). https://doi.org/10.1007/s00289-016-1653-z

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00289-016-1653-z

Keywords