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Mechanisms controlling diversification of olfactory sensory neuron classes

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Abstract

Animals survive in harsh and fluctuating environments using sensory neurons to detect and respond to changes in their surroundings. Olfactory sensory neurons are essential for detecting food, identifying danger, and sensing pheromones. The ability to sense a large repertoire of different types of odors is crucial to distinguish between different situations, and is achieved through neuronal diversity within the olfactory system. Here, we review the developmental mechanisms used to establish diversity of olfactory sensory neurons in various model organisms, including Caenorhabditis elegans, Drosophila, and vertebrate models. Understanding and comparing how different olfactory neurons develop within the nervous system of different animals can provide insight into how the olfactory system is shaped in humans.

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Acknowledgements

This work is supported by an Alfred P. Sloan Research Fellowship and an NIH grant R01GM098026 to C.-F.C.

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Author notes

    Authors and Affiliations

    1. Department of Biological Sciences, University of Illinois at Chicago, 900 S. Ashland Avenue, MC 567, Chicago, IL, 60607, USA

      Yi-Wen Hsieh, Amel Alqadah & Chiou-Fen Chuang

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    1. Yi-Wen Hsieh
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    2. Amel Alqadah
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    3. Chiou-Fen Chuang
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    Corresponding author

    Correspondence to Chiou-Fen Chuang.

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    Yi-Wen Hsieh and Amel Alqadah contributed equally to this work.

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    Hsieh, YW., Alqadah, A. & Chuang, CF. Mechanisms controlling diversification of olfactory sensory neuron classes. Cell. Mol. Life Sci. 74, 3263–3274 (2017). https://doi.org/10.1007/s00018-017-2512-2

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    • DOI: https://doi.org/10.1007/s00018-017-2512-2

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