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Fabrication of lavender essential oil-loaded polyurethane nanoparticles via a facile swelling-diffusion method as hydrocolloid agents for wound healing applications

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Abstract

Colloidal agents or polymeric nanoparticles, in which the drug can be encapsulated and released in a controlled way, are currently interesting approaches for wound healing owing to their intrinsic properties. This work proposes a facile and efficient strategy for developing polyurethane (PU) nanoparticles as modern hydrocolloid dressing agents for wound healing applications. Preformed PU nanoparticles (hydrocolloid) were utilized as a template for simple swelling-diffusion of lavender essential oil (LO). The LO phase dissolved in ethanol/water mixture at different volume ratios was gently mixed with PU hydrocolloid. Due to the high miscibility between LO and the PU matrix, LO diffused and entrapped into the PU nanoparticles. The effect of ethanol/water ratios on the colloidal stability, encapsulation efficiency (%EE), and loading capacity (%LC) of the obtained LO-loaded PU (LO@PU) nanoparticles was studied. With ethanol/water at 0/100, the stable LO@PU nanoparticles with high EE and LC of 59.67% and 27.98%, were obtained. The release behavior of LO from the LO@PU nanoparticles in phosphate buffer at pH 8.5 (suitable for practical use in wound healing applications) showed sustained release for 192 h. The cytotoxicity assay performed using the fibroblast cells showed a high cell viability of ~ 80% at the highest concentration of nanoparticles (1 mg/mL), reflecting their biocompatibility. The encapsulated PU nanoparticles can be made into a transparent soft film, which showed antibacterial activity against both Staphylococcus aureus and Escherichia coli. These results suggest that the prepared LO@PU hydrocolloid has a high potential for wound healing applications.

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Acknowledgements

This work was supported by the Thailand Science Research and Innovation Fundamental Fund fiscal year 2024. The authors thank the Center of Excellence in Functional Advanced Materials Engineering (CoE FAME), Thammasat University, and the National Nanotechnology Center (NANOTEC). S.R. acknowledges the scholarship under the Thailand Advanced Institute of Science and Technology and Tokyo Institute of Technology (TAIST-Tokyo Tech) program, awarded by SIIT, Thammasat University, and the National Science and Technology Development Agency (NSTDA), funded by the National Research Council of Thailand (NRCT).

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Authors and Affiliations

  1. School of Integrated Science and Innovation, Sirindhorn International Institute of Technology (SIIT), Thammasat University, Khlong Luang District, Pathum Thani, 12121, Thailand

    Sosna Sri Rahayu, Chariya Kaewsaneha & Pakorn Opaprakasit

  2. National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), Khlong Luang District, 12120, Pathum Thani, Thailand

    Yodsathorn Wongngam & Duangporn Polpanich

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  1. Sosna Sri Rahayu
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Sosna Sri Rahayu, Yodsathorn Wongngam and Pakorn Opaprakasit. The first draft of the manuscript was written by Chariya Kaewsaneha and Duangporn Polpanich, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Chariya Kaewsaneha.

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Rahayu, S.S., Kaewsaneha, C., Opaprakasit, P. et al. Fabrication of lavender essential oil-loaded polyurethane nanoparticles via a facile swelling-diffusion method as hydrocolloid agents for wound healing applications. emergent mater. (2024). https://doi.org/10.1007/s42247-024-00887-8

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