Phenothiazinum

Phenothiazinum est in chemia compositum organicum formulae S(C₆H₄)₂NH. Nonnulla phenothiazinorum medicamenta antipsychotica ad schizophreniam therapiam nota sunt^[1].

Structura chemica

Structura phenothiazini est 10H-di-benzo-[b,e]-1,4-thiazinum.

Medicamenta antipsychotica

Medicamenta antipsychotica cum phenothiazino in greges tres dividuntur: composita aliphatica, piperidina, piperazina.

Grex	Effectus autonomicus	Exemplum	Sedativum	Reactio adversa
Composita aliphatica
	moderate	Chlorpromazinum	forte	moderate
		Promazinum	moderate	moderate
		Triflupromazinum	forte	moderate/forte
		Laevomepromazinum	fortissime	minime
Piperidina	fuerte	Mesoridazinum	forte	lente
Piperidina	fuerte	Thioridazinum	forte	lente
Piperazina	lente	Fluphenazinum	lente/moderate	forte
		Perphenazinum	lente/moderate	forte
		Prochlorperazinum
		Trifluoperazinum	moderate	forte

Effectus biologici

Apud homines et animales phenothiazina effectus phototoxicos perficiunt: Phenothiazinum una cum luce reactionem adversariam cutaneam provocare possunt.

Notae

↑ Jaszczyszyn A, Gasiorowski1 K, Swiatek P, Malinka W, Cieslik-Boczula K, Petrus J, Czarnik-Matusewicz B (2012). "Chemical structure of phenothiazines and their biological activity". Pharmacol Rep 64: 16-23

Nexus interni

[1] Jaszczyszyn A, Gasiorowski1 K, Swiatek P, Malinka W, Cieslik-Boczula K, Petrus J, Czarnik-Matusewicz B (2012). "Chemical structure of phenothiazines and their biological activity". Pharmacol Rep 64: 16-23

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