Network propagation-based machine learning framework.
We consider node feature vector should contains all of information(Chemical,ATC,Target...)
The application of NetPro:
Drug combination prediction. Data from DrugBank, DrugCombDB, SIDER et al.
Five steps for NetPro:
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Constructing the multiplex drug-drug association network.
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Performancing random walk with restart to identify closely related drug pairs.
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Establishing random forest models to predict synergistic drug combinations.
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Evaluating the toxicity risk of drug combinations with strong synergy.
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Predicting the therapeutic potential of drug combinations for different cancer types.