Comparing the structures of antibodies and nanobodies relative to each other in a 3D and 2D visualization platform with respect to SARS-CoV2 spike glycoprotein will allow us to understand the details of the intermolecular interactions.

Antibodies are widely used in a number of applications. Understanding the particular residue or domain epitopes-paratopes interactions can help in predicting binding interactions which can assist in the area of drug design. A functional understanding of antibody-nanobody interactions within the SARS-CoV2 RBD domain with computational tools can complement and accelerate the area of therapeutics. The calculation of binding strenghts and interaction energy for the variants of interest with position matching epitopes and paratopes will be of interest as we visually probe and compare using the 2-D interaction networks.

Reference literature: IEDB, NCBI, NextStrain, GISAID, CovabDAB, MMDB, PDB, UniProt