Narasin

Narasin
Clinical data
Other names	(4S)-4-methyl-salinomycin
AHFS/Drugs.com	International Drug Names
ATCvet code	QP51BB04 (WHO) QP51BB54 (WHO);
Identifiers
	IUPAC name (2R)-2-[(2R,3S,5S,6R)-6-[(1S,2S,3S,5R)-5- [(2S,5S,7R,9S,10S,12R,15R)-2-[(2R,5R,6S)-5-ethyl-5-hydroxy-6-methyl-2-tetrahydropyranyl]-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.57.35]pentadec-13-en-9-yl]-2-hydroxy-1,3-dimethyl-4-oxoheptyl]-3,5-dimethyl-2-tetrahydropyranyl]butanoic acid;
CAS Number	55134-13-9 ;
PubChem CID	65452;
ChemSpider	58911;
UNII	DZY9VU539P;
CompTox Dashboard (EPA)	DTXSID2046707 ;
ECHA InfoCard	100.122.892
Chemical and physical data
Formula	C43H72O11
Molar mass	765.038 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C([C@@H](C)[C@@H](O)[C@H](C)[C@]5([H])O[C@]([C@@H](CC)C(O)=O)([H])[C@@H](C)C[C@@H]5C)[C@H](CC)[C@@]1([H])O[C@@]2(O[C@@]3(CC[C@]([C@]4([H])O[C@@H](C)[C@@](O)(CC)CC4)(C)O3)[C@H](O)C=C2)[C@H](C)C[C@@H]1C;
	InChI InChI=1S/C43H72O11/c1-12-30(35(46)27(8)34(45)28(9)36-23(4)21-24(5)37(51-36)31(13-2)39(47)48)38-25(6)22-26(7)42(52-38)18-15-32(44)43(54-42)20-19-40(11,53-43)33-16-17-41(49,14-3)29(10)50-33/h15,18,23-34,36-38,44-45,49H,12-14,16-17,19-22H2,1-11H3,(H,47,48)/t23-,24-,25-,26+,27-,28-,29-,30-,31+,32+,33+,34+,36+,37+,38-,40-,41+,42-,43-/m0/s1; Key:VHKXXVVRRDYCIK-CWCPJSEDSA-N;
	(verify)

Narasin is a coccidiostat and antibacterial agent.^[1]^[2] It is a derivative of salinomycin with an additional methyl group. Narasin is produced by fermentation of a strain of Streptomyces aureofaciens.^[3]

References

^ Gerhold RW, Fuller AL, Lollis L, Parr C, McDougald LR (March 2011). "The efficacy of anticoccidial products against Eimeria spp. in northern bobwhites". Avian Diseases. 55 (1): 59–64. doi:10.1637/9572-101310-Reg.1. PMID 21500637. S2CID 30943649.
^ Fitzgerald PR, Mansfield ME (July 1989). "Effects of inoculations with Eimeria zuernii on young calves treated with decoquinate or narasin with or without dexamethasone". American Journal of Veterinary Research. 50 (7): 1056–1059. PMID 2774323.
^ Anadón A, Martínez-Larrañaga MR (2014). "Veterinary Drugs Residues: Coccidiostats". Encyclopedia of Food Safety. pp. 63–75. doi:10.1016/B978-0-12-378612-8.00246-8. ISBN 9780123786135.

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