Composition of Anesthesia Duration betweem Interathecal Ketamine and Dexmedetomidine Administration as an Aduvant to ۰.۵% Bupivacaine in Spinal Anesthetia for Lower Extremity Surgery
Publish Year: 1403
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JMCH-7-12_019
تاریخ نمایه سازی: 19 دی 1403
Abstract:
Spinal anesthesia is the process of blocking nerve cells in the subarachnoid space with a local anesthetic drug. Bupivacaine is the most common agent, but the duration is often short-lived. The duration can be extended by adding adjuvants such as ketamine and dexmedetomidine. Generally, dexmedetomidine induces activation of α۲ agonist receptors in the spinal cord which causes a decrease in the transmission of nociceptive signals including substance P and glutamate, while ketamine as a single anesthetic agent produces psychomimetic disturbances and inadequate analgesia. Therefore, ketamine and dexmedetomidine are adjuvants for intrathecal bupivacaine. This study aimed to compare the duration of anesthesia between the administration of intrathecal ketamine and dexmedetomidine as an adjuvant to bupivacaine ۰.۵% in spinal anesthesia. A randomized cinical trial design was used with double blinds and the samples were divided into group A (adjuvant ketamine), given hyperbaric Bupivacaine ۰.۵% ۱۵mg with adjuvant Ketamine ۵ mg and group B (Bupivacaine) administrated adjuvant dexmedetomidine ۵ mcg. The results showed that there were ۳۰ samples with a distribution of ۱۵ in each group. A significant difference was found in sensory and motor duration (p<۰.۰۰۱). The average sensory duration in the ketamine group was ۱۸۵ minutes and in the dexmedetomidine group, it was ۲۹۳ minutes. The motor duration in the ketamine group was found to be an average of ۲۰۰ minutes and for dexmedetomidine, it was ۳۰۳ minutes. Based on the results, the dexmedetomidine group had a longer duration of anesthesia than ketamine in spinal anesthesia.
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Authors
Tasrif Hamdi
Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Sumatera Utara, Adam Malik Hospital, Medan, Indonesia
Muhammad Ihsan
Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Sumatera Utara, Adam Malik Hospital, Medan, Indonesia
Isak Lambas
Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Sumatera Utara, Adam Malik Hospital, Medan, Indonesia
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