Association of ABCB۱(Rs۱۰۲۷۶۰۳۶, C/T) Gene, IL-۱۸, and TNFα as Risk Factors for Nephrotic Syndrome Incidence
Publish Year: 1403
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_RBMB-13-1_008
تاریخ نمایه سازی: 18 آبان 1403
Abstract:
Background: The most common cause of Nephrotic Syndrome (NS) in children is idiopathic NS, also called nephrosis. The most prominent clinical signs are hyperlipidemia, severe proteinuria, edema, swelling of body tissues, and an increased risk of infection. The object of this study was to examine the correlation of the ABCB۱ gene (rs۱۰۲۷۶۰۳۶, C > T), IL-۱۸, and TNFα to the prevalence of NS among Egyptian children having NS.
Methods: This study included ۱۰۰ participants with NS and ۱۰۰ healthy controls. To analyze the ABCB۱ gene (rs۱۰۲۷۶۰۳۶ C >T) variant PCR technique was used. IL-۱۸ and TNF levels were estimated using Enzyme-Linked Immunosorbent Assay (ELISA).
Results: Increased frequency of CT and TT genotypes of the ABCB۱ gene (rs۱۰۲۷۶۰۳۶ C / T) in NS patients compared to controls, with p-value = ۰.۰۰۱, OR = ۲.۲۷۰, CI = (۱.۵۵۰-۳.۳۲۷) for CT genotype and p-value = ۰.۰۰۱, OR = ۵.۰۷۰, CI = (۲.۴۶۳-۱۰.۴۳۸) for TT genotype. The frequencies of ABCB۱ (rs۱۰۲۷۶۰۳۶ C >T) genotypes were statistically significant in the dominant model (OR ۲.۵۶۰; p< ۰.۰۰۱) and in the recessive model OR, ۳.۲۳۱; p= ۰.۰۰۱). Significantly high levels of both IL-۱۸ and TNFα were found in NS patients compared to controls.
Conclusion: The ABCB۱gene (rs۱۰۲۷۶۰۳۶ C/T), IL-۱۸, and TNFα are associated with the prevalence of NS in Egyptian children and might be considered as independent risk factors for its incidence.
Keywords:
ATP Binding Cassette Transporter , Interleukin-۱۸ , Polymerase Chain Reaction , Subfamily B , Tumor Necrosis Factor-alpha.
Authors
Eglal Aly Hassan
Chemistry Department, Faculty of Science, Mansoura University, Mansoura ۳۵۵۱۶, Egypt.
Afaf Mohamed Elsaid
Genetic Unit, Children Hospital, Mansoura University, Mansoura ۳۵۵۱۶, Egypt.
Ahmed Mahmoud El-Refaey
Department of Pediatrics, Mansoura University Children's Hospital, Mansoura University, Mansoura ۳۵۵۱۶, Egypt.
Mohammed Abou Elzahab
Chemistry Department, Faculty of Science, Mansoura University, Mansoura ۳۵۵۱۶, Egypt.
Magdy Mahfouz Youssef
Chemistry Department, Faculty of Science, Mansoura University, Mansoura ۳۵۵۱۶, Egypt.
Rehab Elmougy
Chemistry Department, Faculty of Science, Mansoura University, Mansoura ۳۵۵۱۶, Egypt.
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